Kantarci Kejal, Murray Melissa E, Schwarz Christopher G, Reid Robert I, Przybelski Scott A, Lesnick Timothy, Zuk Samantha M, Raman Mekala R, Senjem Matthew L, Gunter Jeffrey L, Boeve Bradley F, Knopman David S, Parisi Joseph E, Petersen Ronald C, Jack Clifford R, Dickson Dennis W
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Department of Pathology and Laboratory Medicine, Mayo Clinic, Jacksonville, FL, USA.
Neurobiol Aging. 2017 Aug;56:172-179. doi: 10.1016/j.neurobiolaging.2017.04.024. Epub 2017 May 4.
Pattern of diffusion tensor MRI (DTI) alterations were investigated in pathologically-staged Alzheimer's disease (AD) patients (n = 46). Patients with antemortem DTI studies and a range of AD pathology at autopsy were included. Patients with a high neurofibrillary tangle (NFT) stage (Braak IV-VI) had significantly elevated mean diffusivity (MD) in the crus of fornix and ventral cingulum tracts, precuneus, and entorhinal white matter on voxel-based analysis after adjusting for age and time from MRI to death (p < 0.001). Higher MD and lower fractional anisotropy in the ventral cingulum tract, entorhinal, and precuneus white matter was associated with higher Braak NFT stage and clinical disease severity. There were no MD and fractional anisotropy differences among the low (none and sparse) and high (moderate and frequent) β-amyloid neuritic plaque groups. The NFT pathology of AD is associated with DTI alterations involving the medial temporal limbic connections and medial parietal white matter. This pattern of diffusion abnormalities is also associated with clinical disease severity.
对病理分期的阿尔茨海默病（AD）患者（n = 46）的扩散张量磁共振成像（DTI）改变模式进行了研究。纳入了生前进行DTI研究且尸检时有一系列AD病理学表现的患者。在基于体素的分析中，经年龄和从MRI到死亡的时间校正后，神经原纤维缠结（NFT）处于高分期（Braak IV - VI期）的患者在穹窿脚、腹侧扣带束、楔前叶和内嗅白质中的平均扩散率（MD）显著升高（p < 0.001）。腹侧扣带束、内嗅和楔前叶白质中较高的MD和较低的分数各向异性与较高的Braak NFT分期和临床疾病严重程度相关。低（无和稀疏）和高（中度和频繁）β - 淀粉样蛋白神经炎斑块组之间的MD和分数各向异性没有差异。AD的NFT病理学与涉及内侧颞叶边缘连接和内侧顶叶白质的DTI改变有关。这种扩散异常模式也与临床疾病严重程度相关。
