McNally Richard J Q, James Peter W, Blakey Karen, Basta Nermine O, Norman Paul D, Pearce Mark S
Institute of Health & Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, England, UK.
Institute of Health & Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, England, UK.
Spat Spatiotemporal Epidemiol. 2017 Jun;21:25-36. doi: 10.1016/j.sste.2017.02.002. Epub 2017 Feb 27.
Previously excesses in incident cases of leukaemia and non-Hodgkin lymphoma have been observed amongst young people born or resident in Seascale, Cumbria. These excesses have not been seen more recently. It is postulated that the former apparent increased risk was related to 'unusual population mixing', which is not present in recent years. This study investigated changes in measures of population mixing from 1951-2001. Comparisons were made between three specified areas. Area-based measures were calculated (migration, commuting, deprivation, population density). All areas have become more affluent, although Seascale was consistently the most affluent. Seascale has become less densely populated, with less migration into the ward and less diversity with respect to migrants' origin. There have been marked changes in patterns of population mixing throughout Cumbria. Lesser population mixing has been observed in Seascale in recent decades. Changes in pattern and nature of population mixing may explain the lack of recent excesses.
此前，在出生于或居住在坎布里亚郡西斯科尔的年轻人中，已观察到白血病和非霍奇金淋巴瘤的发病病例出现过异常增多的情况。不过，近期并未再出现此类异常增多现象。据推测，之前明显增加的风险与“异常的人口混居”有关，而近年来这种情况已不存在。本研究调查了1951年至2001年期间人口混居情况的变化。对三个特定区域进行了比较。计算了基于区域的各项指标（迁移、通勤、贫困程度、人口密度）。所有区域都变得更加富裕，尽管西斯科尔一直是最富裕的。西斯科尔的人口密度降低，迁入该病房的人口减少，移民来源的多样性也降低。整个坎布里亚郡的人口混居模式发生了显著变化。近几十年来，在西斯科尔观察到人口混居情况有所减少。人口混居模式和性质的变化可能解释了近期未出现异常增多情况的原因。
