Sakai Seigo, Hien Vu Thi Thu, Tuyen Le Danh, Duc Ha Anh, Masuda Yasunobu, Yamamoto Shigeru
Institute of Technology, R&D Division, Kewpie Corporation.
National Institute of Nutrition.
J Nutr Sci Vitaminol (Tokyo). 2017;63(2):120-124. doi: 10.3177/jnsv.63.120.
Bone mass decreases along with aging, especially for women after menopause because of lower estrogen secretion together with low calcium intake. This study was conducted to study the effect of eggshell calcium supplementation on bone mass in 54 postmenopausal Vietnamese women living in a farming area about 60 km from Hanoi, Vietnam. Sets of 3 subjects matched by age, bone mass, BMI and calcium intake were divided randomly into 3 groups with 18 subjects in each group. The eggshell calcium group was administered 300 mg/d calcium from eggshell, the calcium carbonate group 300 mg/d calcium from calcium carbonate and the placebo group received no calcium supplementation. Bone mass (Speed of Sound (SOS)) was measured at the beginning (the baseline), the middle (6th month) and the end of the study (12th month) by the single blind method. SOS of the eggshell group increased significantly at 12 mo (p<0.05) and was significantly higher than that of the placebo and calcium carbonate groups at 12 mo (p<0.05). The SOS of the calcium carbonate group tended to be higher than that of the placebo group but without a significant difference (p>0.05). In conclusion, eggshell calcium was more effective in increasing bone mass than calcium carbonate in postmenopausal Vietnamese women.
骨量会随着年龄增长而下降,尤其是绝经后的女性,这是由于雌激素分泌减少以及钙摄入量低所致。本研究旨在探讨补充蛋壳钙对54名居住在越南河内约60公里外农村地区的绝经后越南女性骨量的影响。将年龄、骨量、体重指数和钙摄入量相匹配的3名受试者分为一组,随机分为3组,每组18名受试者。蛋壳钙组给予300毫克/天的蛋壳钙,碳酸钙组给予300毫克/天的碳酸钙,安慰剂组不补充钙。采用单盲法在研究开始时(基线)、中期(第6个月)和结束时(第12个月)测量骨量(声速(SOS))。蛋壳钙组在12个月时SOS显著增加(p<0.05),且在12个月时显著高于安慰剂组和碳酸钙组(p<0.05)。碳酸钙组的SOS有高于安慰剂组的趋势,但无显著差异(p>0.05)。总之,在绝经后越南女性中,蛋壳钙在增加骨量方面比碳酸钙更有效。