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Efficacy comparison of lyophilised black raspberries and combination of celecoxib and PBIT in prevention of carcinogen-induced oesophageal cancer in rats.冻干黑莓与塞来昔布和PBIT联合用药在预防致癌物诱导大鼠食管癌中的疗效比较
J Funct Foods. 2016 Dec;27:84-94. doi: 10.1016/j.jff.2016.08.044. Epub 2016 Sep 16.
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Chemopreventive effects of a selective nitric oxide synthase inhibitor on carcinogen-induced rat esophageal tumorigenesis.一种选择性一氧化氮合酶抑制剂对致癌物诱导的大鼠食管肿瘤发生的化学预防作用。
Cancer Res. 2004 May 15;64(10):3714-7. doi: 10.1158/0008-5472.CAN-04-0302.
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Chemopreventive properties of black raspberries in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis: down-regulation of cyclooxygenase-2, inducible nitric oxide synthase, and c-Jun.黑树莓对N-亚硝基甲基苄胺诱导的大鼠食管肿瘤发生的化学预防特性：环氧合酶-2、诱导型一氧化氮合酶和c-Jun的下调
Cancer Res. 2006 Mar 1;66(5):2853-9. doi: 10.1158/0008-5472.CAN-05-3279.
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Chemoprevention of colonic aberrant crypt foci by an inducible nitric oxide synthase-selective inhibitor.诱导型一氧化氮合酶选择性抑制剂对结肠异常隐窝病灶的化学预防作用
Carcinogenesis. 1999 Apr;20(4):641-4. doi: 10.1093/carcin/20.4.641.
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Chemopreventive effects of PBI-Se, a selenium-containing analog of PBIT, on AOM-induced aberrant crypt foci in F344 rats.PBI-Se（一种含硒 PBIT 类似物）对 AOM 诱导的 F344 大鼠结肠异常隐窝病灶的化学预防作用。
Oncol Rep. 2013 Aug;30(2):952-60. doi: 10.3892/or.2013.2483. Epub 2013 May 23.
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Suppression of Oxidative Stress and NFκB/MAPK Signaling by Lyophilized Black Raspberries for Esophageal Cancer Prevention in Rats.冻干黑莓对大鼠食管癌预防作用的氧化应激及NFκB/MAPK信号通路抑制作用研究
Nutrients. 2017 Apr 22;9(4):413. doi: 10.3390/nu9040413.
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Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor.一种选择性诱导型一氧化氮合酶抑制剂在结肠癌发生过程中的化学预防特性，单独给药或与选择性环氧化酶-2抑制剂塞来昔布联合给药时的情况。
Cancer Res. 2002 Jan 1;62(1):165-70.
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The selenium analog of the chemopreventive compound S,S'-(1,4-phenylenebis[1,2-ethanediyl])bisisothiourea is a remarkable inducer of apoptosis and inhibitor of cell growth in human non-small cell lung cancer.化学预防化合物S,S'-(1,4-亚苯基双[1,2-乙二基])双异硫脲的硒类似物是人类非小细胞肺癌中一种显著的细胞凋亡诱导剂和细胞生长抑制剂。
Chem Biol Interact. 2009 Jul 15;180(2):158-64. doi: 10.1016/j.cbi.2009.03.003. Epub 2009 Mar 20.
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Black raspberries inhibit N-nitrosomethylbenzylamine (NMBA)-induced angiogenesis in rat esophagus parallel to the suppression of COX-2 and iNOS.黑树莓抑制N-亚硝基甲基苄胺（NMBA）诱导的大鼠食管血管生成，这与环氧化酶-2（COX-2）和诱导型一氧化氮合酶（iNOS）的抑制作用相平行。
Carcinogenesis. 2006 Nov;27(11):2301-7. doi: 10.1093/carcin/bgl109. Epub 2006 Jun 15.
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PBISe, a novel selenium-containing drug for the treatment of malignant melanoma.PBISe，一种用于治疗恶性黑色素瘤的新型含硒药物。
Mol Cancer Ther. 2008 May;7(5):1297-308. doi: 10.1158/1535-7163.MCT-07-2267.
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Protein and Peptide-Based Nanotechnology for Enhancing Stability, Bioactivity, and Delivery of Anthocyanins.基于蛋白质和肽的纳米技术增强花色苷的稳定性、生物活性和递送
Adv Healthc Mater. 2023 Oct;12(25):e2300473. doi: 10.1002/adhm.202300473. Epub 2023 Aug 3.
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Predicting Dose-Dependent Carcinogenicity of Chemical Mixtures Using a Novel Hybrid Neural Network Framework and Mathematical Approach.使用新型混合神经网络框架和数学方法预测化学混合物的剂量依赖性致癌性。
Toxics. 2023 Jul 12;11(7):605. doi: 10.3390/toxics11070605.
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Chemopreventive Properties of Black Raspberries and Strawberries in Esophageal Cancer Review.黑树莓和草莓对食管癌的化学预防特性综述。
Antioxidants (Basel). 2022 Sep 15;11(9):1815. doi: 10.3390/antiox11091815.
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Onion anthocyanins: Extraction, stability, bioavailability, dietary effect, and health implications.洋葱花青素：提取、稳定性、生物利用度、饮食效应及对健康的影响
Front Nutr. 2022 Jul 27;9:917617. doi: 10.3389/fnut.2022.917617. eCollection 2022.
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Anthocyanins in Colorectal Cancer Prevention Review.花青素在结直肠癌预防中的综述。
Antioxidants (Basel). 2021 Oct 12;10(10):1600. doi: 10.3390/antiox10101600.
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Chemopreventive Effect of Dietary Anthocyanins against Gastrointestinal Cancers: A Review of Recent Advances and Perspectives.膳食花色苷预防胃肠道癌症的作用：最新进展和展望的综述。
Int J Mol Sci. 2020 Sep 8;21(18):6555. doi: 10.3390/ijms21186555.
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Inhibition of esophageal cancer growth through the suppression of PI3K/AKT/mTOR signaling pathway.通过抑制PI3K/AKT/mTOR信号通路抑制食管癌生长。
Onco Targets Ther. 2019 Sep 17;12:7637-7647. doi: 10.2147/OTT.S205457. eCollection 2019.
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Chemopreventive Effects of Strawberry and Black Raspberry on Colorectal Cancer in Inflammatory Bowel Disease.草莓和黑莓对炎症性肠病中结直肠癌的化学预防作用。
Nutrients. 2019 Jun 3;11(6):1261. doi: 10.3390/nu11061261.
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Suppression of Oxidative Stress and NFκB/MAPK Signaling by Lyophilized Black Raspberries for Esophageal Cancer Prevention in Rats.冻干黑莓对大鼠食管癌预防作用的氧化应激及NFκB/MAPK信号通路抑制作用研究
Nutrients. 2017 Apr 22;9(4):413. doi: 10.3390/nu9040413.
本文引用的文献
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Anthocyanins From the Fruit of Vitis coignetiae Pulliat Potentiate the Cisplatin Activity by Inhibiting PI3K/Akt Signaling Pathways in Human Gastric Cancer Cells.山葡萄果实中的花色苷通过抑制人胃癌细胞中的PI3K/Akt信号通路增强顺铂活性。
J Cancer Prev. 2015 Mar;20(1):50-6. doi: 10.15430/JCP.2015.20.1.50.
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Strawberry phytochemicals inhibit azoxymethane/dextran sodium sulfate-induced colorectal carcinogenesis in Crj: CD-1 mice.草莓植物化学物质可抑制Crj:CD-1小鼠中由氧化偶氮甲烷/葡聚糖硫酸钠诱导的结直肠癌发生。
Nutrients. 2015 Mar 10;7(3):1696-715. doi: 10.3390/nu7031696.
3
Anthocyanins from black rice (Oryza sativa L.) demonstrate antimetastatic properties by reducing MMPs and NF-κB expressions in human oral cancer CAL 27 cells.黑米（Oryza sativa L.）中的花青素通过降低人口腔癌CAL 27细胞中基质金属蛋白酶（MMPs）和核因子κB（NF-κB）的表达来展现抗转移特性。
Nutr Cancer. 2015;67(2):327-38. doi: 10.1080/01635581.2015.990576. Epub 2015 Feb 6.
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Overexpression of human β-defensin 2 promotes growth and invasion during esophageal carcinogenesis.人β-防御素2的过表达在食管癌发生过程中促进生长和侵袭。
Oncotarget. 2014 Nov 30;5(22):11333-44. doi: 10.18632/oncotarget.2416.
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Chemoprevention of esophageal cancer with black raspberries, their component anthocyanins, and a major anthocyanin metabolite, protocatechuic acid.用黑树莓、其成分花青素以及一种主要的花青素代谢产物原儿茶酸进行食管癌的化学预防。
Cancer Prev Res (Phila). 2014 Jun;7(6):574-84. doi: 10.1158/1940-6207.CAPR-14-0003. Epub 2014 Mar 25.
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Cancer statistics, 2014.癌症统计数据，2014 年。
CA Cancer J Clin. 2014 Jan-Feb;64(1):9-29. doi: 10.3322/caac.21208. Epub 2014 Jan 7.
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Prognostic significance of XIAP and NF-κB expression in esophageal carcinoma with postoperative radiotherapy.XIAP 和 NF-κB 表达在食管癌术后放疗中的预后意义。
World J Surg Oncol. 2013 Nov 5;11:288. doi: 10.1186/1477-7819-11-288.
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ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer.ERK 和 AKT 信号通路协同作用调控 survivin 的翻译表达促进结直肠癌的转移进展。
Oncogene. 2014 Apr 3;33(14):1828-39. doi: 10.1038/onc.2013.122. Epub 2013 Apr 29.
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Chemoprevention of head and neck cancer by simultaneous blocking of epidermal growth factor receptor and cyclooxygenase-2 signaling pathways: preclinical and clinical studies.通过同时阻断表皮生长因子受体和环氧化酶-2 信号通路预防头颈部癌症：临床前和临床研究。
Clin Cancer Res. 2013 Mar 1;19(5):1244-56. doi: 10.1158/1078-0432.CCR-12-3149. Epub 2013 Feb 19.
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Randomized phase II trial of lyophilized strawberries in patients with dysplastic precancerous lesions of the esophagus.随机Ⅱ期临床试验：冻干草莓治疗食管发育不良癌前病变患者。
Cancer Prev Res (Phila). 2012 Jan;5(1):41-50. doi: 10.1158/1940-6207.CAPR-11-0469. Epub 2011 Dec 1.
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