Meirelles Lyghia Maria Araújo, Raffin Fernanda Nervo
Post- Program on Development and Technological Innovation in Medications, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte.
J Pharm Pharm Sci. 2017;20(0):115-134. doi: 10.18433/J3R617.
There has been a growing trend in recent years for the development of hybrid materials, called composites, based on clay and polymers, whose innovative properties render them attractive for drug release. The objective of this manuscript was to conduct a review of original articles on this topic published over the last decade and of the body of patents related to these carriers. A scientific prospection was carried out spanning the period from 2005 to 2015 on the Web of Science database. The technological prospection encompassed the United States Patent and Trademark Office, the European Patent Office, the World International Patent Office and the National Institute of Industrial Property databases, filtering patents with the code A61K. The survey revealed a rise in the number of publications over the past decade, confirming the potential of these hybrids for use in pharmaceutical technology. Through interaction between polymer and clay, the mechanical and thermal properties of composites are enhanced, promoting stable, controlled drugs release in biological media. The most cited clays analyzed in the articles was montmorillonite, owing to its high surface area and capacity for ion exchange. The polymeric part is commonly obtained by copolymerization, particularly using acrylate derivatives. The hybrid materials are obtained mainly in particulate form on a nanometric scale, attaining a modified release profile often sensitive to stimuli in the media. A low number of patents related to the topic were found. The World International Patent Office had the highest number of lodged patents, while Japan was the country which published the most patents. A need to broaden the application of this technology to include more therapeutic classes was identified. Moreover, the absence of regulation of nanomaterials might explain the disparity between scientific and technological output. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.
近年来，基于粘土和聚合物开发的混合材料（称为复合材料）呈增长趋势，其创新特性使其在药物释放方面颇具吸引力。本手稿的目的是回顾过去十年发表的关于该主题的原创文章以及与这些载体相关的专利。在2005年至2015年期间对科学引文索引数据库进行了科学展望。技术展望涵盖美国专利商标局、欧洲专利局、世界知识产权组织国际局和国家工业产权数据库，筛选代码为A61K的专利。调查显示，过去十年出版物数量有所增加，证实了这些混合物在制药技术中的应用潜力。通过聚合物与粘土之间的相互作用，复合材料的机械和热性能得到增强，促进了生物介质中药物的稳定、可控释放。文章中分析的被引用最多的粘土是蒙脱石，这是由于其高比表面积和离子交换能力。聚合物部分通常通过共聚获得，特别是使用丙烯酸酯衍生物。混合材料主要以纳米级颗粒形式获得，实现了通常对介质刺激敏感的缓释特性。发现与该主题相关的专利数量较少。世界知识产权组织国际局提交的专利数量最多，而日本是公布专利最多的国家。确定需要扩大该技术的应用范围，以涵盖更多治疗类别。此外，纳米材料缺乏监管可能解释了科技产出之间的差异。本文接受出版后审查。注册读者（见“致读者”）可通过点击本期目录页面上的摘要进行评论。
