de Souza Sene Ingridi, Costa Vladimir, Pauli Gisele Elias Nunes, Bechtold Ivan H, Nunes Livio Cesar Cunha, Eiras Carla, Costa Carlos Henrique Nery
Universidade Federal do Piaui, Teresina-PI, Brazil.
Instituto de Doencas Topicais Natan Portella (IDTNP), Laboratorio de Leishmaniose Teresina, Piaui, Brazil.
Recent Pat Biotechnol. 2018;12(3):221-228. doi: 10.2174/1872208312666180321113248.
Interleukin-6 (IL-6) is a multifunctional cytokine that plays a crucial role not only in the immune system but also in numerous biological processes. Elevated IL-6 levels have been observed in many types of cancer and inflammatory diseases. Among the techniques that have been used to quantify IL-6, a Lateral Flow Assay (LFA) is one of the most promising.
The objective of this study was to perform a technological and scientific exploration of the development of an LFA for IL-6.
The Instituto Nacional de Propriedade Industrial-INPI (Brazil), European Patent Office - Espacenet, and United States Patent and Trademark Office-USPTO were used for the technological prospection to consider all the patents regarding an LFA for IL-6 detection. For the scientific investigation, the following periodic databases were used: Web of Science, Science Direct, PubMed, and Scielo, and were monitored from 2007 to May 2017.
We found no patents based on the searched keywords, and a limited number of scientific articles were found. Therefore, the development of an LFA sensor for the detection of IL-6 appears to be innovative with significant biotechnological importance, creating a technology transfer to promote economic and industrial growth.
The development of lateral flow immunosensors for IL-6 is innovative, as we could not find patents describing such a biosensor. Scientific prospection reported two lateral flow immunosensors. However, the test for IL-6 cannot be completed without using some kind of equipment for detection, such as the one we propose in future developments.
白细胞介素-6（IL-6）是一种多功能细胞因子，不仅在免疫系统中发挥关键作用，还参与众多生物学过程。在许多类型的癌症和炎症性疾病中都观察到IL-6水平升高。在用于定量IL-6的技术中，侧向流动分析（LFA）是最具前景的技术之一。
本研究的目的是对用于IL-6的LFA的开发进行技术和科学探索。
利用巴西国家工业产权局（INPI）、欧洲专利局（Espacenet）和美国专利商标局（USPTO）进行技术展望，以考虑所有关于用于检测IL-6的LFA的专利。对于科学调查，使用了以下定期数据库：科学网、科学Direct、PubMed和Scielo，并在2007年至2017年5月期间进行监测。
我们未找到基于搜索关键词的专利，且发现的科学文章数量有限。因此，开发用于检测IL-6的LFA传感器似乎具有创新性，具有重要的生物技术意义，可实现技术转让以促进经济和产业增长。
开发用于IL-6的侧向流动免疫传感器具有创新性，因为我们未找到描述此类生物传感器的专利。科学展望报告了两种侧向流动免疫传感器。然而，在不使用某种检测设备（如我们在未来开发中所提议的设备）的情况下，无法完成IL-6检测。
