Bunge Mary B, Monje Paula V, Khan Aisha, Wood Patrick M
The Miami Project to Cure Paralysis, University of Miami Leonard M. Miller School of Medicine, Miami, FL, United States; Department of Cell Biology, University of Miami Leonard M. Miller School of Medicine, Miami, FL, United States; Department of Neurological Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, FL, United States.
The Miami Project to Cure Paralysis, University of Miami Leonard M. Miller School of Medicine, Miami, FL, United States; Department of Neurological Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, FL, United States.
Prog Brain Res. 2017;231:107-133. doi: 10.1016/bs.pbr.2016.12.012. Epub 2017 Mar 31.
Among the potential therapies designed to repair the injured spinal cord is cell transplantation, notably the use of autologous adult human Schwann cells (SCs). Here, we detail some of the critical research accomplished over the last four decades to establish a foundation that enables these cells to be tested in clinical trials. New culture systems allowed novel information to be gained about SCs, including discovering ways to stimulate their proliferation to acquire adequately large numbers for transplantation into the injured human spinal cord. Transplantation of rat SCs into rat models of spinal cord injury has demonstrated that SCs promote repair of injured spinal cord. Additional work required to gain approval from the Food and Drug Administration for the first SC trial in the Miami Project is disclosed. This trial and a second one now underway are described.
旨在修复受损脊髓的潜在疗法中包括细胞移植，尤其是自体成人雪旺细胞（SCs）的使用。在此，我们详细介绍过去四十年来所完成的一些关键研究，以奠定基础，使这些细胞能够在临床试验中进行测试。新的培养系统使人们能够获取有关雪旺细胞的新信息，包括发现刺激其增殖的方法，以获得足够数量用于移植到受损的人类脊髓中。将大鼠雪旺细胞移植到大鼠脊髓损伤模型中已证明，雪旺细胞可促进受损脊髓的修复。文中还披露了迈阿密项目首个雪旺细胞试验获得美国食品药品监督管理局批准所需的其他工作。本文还描述了该试验以及正在进行的第二项试验。
