Saito H, Sato K, Tomioka H
Department of Microbiology and Immunology, Shimane Medical University, Izumo, Japan.
Tubercle. 1988 Sep;69(3):187-92. doi: 10.1016/0041-3879(88)90020-7.
In vitro antimicrobial activity of rifabutin and rifampicin against various mycobacteria, including the Mycobacterium avium complex, was evaluated by the agar dilution method, using 7H10 agar medium. The activity of rifabutin based on MIC50 and MIC90 was higher than that of rifampicin, against all the acid-fast organisms tested. Microbicidal activity of rifabutin against the M. avium complex phagocytosed in mouse peritoneal or alveolar macrophages was greater than that of rifampicin. Both rifabutin and rifampicin had therapeutic effects against murine infections induced by M. avium complex. Rifabutin was somewhat more effective than rifampicin in mice.
采用琼脂稀释法，以7H10琼脂培养基评估利福布汀和利福平对包括鸟分枝杆菌复合群在内的各种分枝杆菌的体外抗菌活性。基于MIC50和MIC90，利福布汀对所有测试的抗酸菌的活性均高于利福平。利福布汀对小鼠腹腔或肺泡巨噬细胞吞噬的鸟分枝杆菌复合群的杀菌活性大于利福平。利福布汀和利福平对鸟分枝杆菌复合群诱导的小鼠感染均有治疗作用。在小鼠中，利福布汀比利福平稍有效。
