• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

为什么医生没有开出更多的丁丙诺啡?

Why aren't physicians prescribing more buprenorphine?

作者信息

Huhn Andrew S, Dunn Kelly E

机构信息

Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

出版信息

J Subst Abuse Treat. 2017 Jul;78:1-7. doi: 10.1016/j.jsat.2017.04.005. Epub 2017 Apr 12.

DOI:10.1016/j.jsat.2017.04.005
PMID:28554597
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5524453/
Abstract

BACKGROUND & OBJECTIVE: Buprenorphine is an underutilized pharmacotherapy that can play a key role in combating the opioid epidemic. Individuals with opioid use disorder (OUD) often struggle to find physicians that prescribe buprenorphine. Many physicians do not have the waiver to prescribe buprenorphine, and a large proportion of physicians that are waivered do not prescribe to capacity. This study aimed to quantitatively understand why physicians do not utilize buprenorphine for the treatment of OUD more frequently.

METHODS

Physicians (n=558) with and without the waiver to prescribe buprenorphine were surveyed about perceived drawbacks associated with prescribing buprenorphine. Furthermore, resources were identified that would encourage those without the waiver to obtain it, and those with the waiver to accept more new patients. The survey was distributed online to physicians in the spring/summer of 2016 via the American Society for Addiction Medicine and American Medical Association listservs.

RESULTS AND CONCLUSIONS

A logistic regression analysis was used to identify reasons that respondents indicated no willingness to increase prescribing (χ(4)=73.18, p<0.001); main reasons were lack of belief in agonist treatment (OR 3.98, 95% CI, 1.43 to 11.1, p=0.008), lack of time for additional patients (OR 5.54, 95% CI, 3.5 to 8.7, p<0.001), and belief that reimbursement rates are insufficient (OR 2.50, 95% CI, 1.3 to 4.8, p=0.006). Differences between non-waivered and waivered physicians concerning attitudes toward buprenorphine treatment as well as resources that would increase willingness to prescribe are also discussed. Identifying barriers to buprenorphine utilization is crucial in expanding treatment options for individuals with OUD.

摘要

背景与目的

丁丙诺啡是一种未得到充分利用的药物疗法,在对抗阿片类药物流行方面可发挥关键作用。患有阿片类药物使用障碍(OUD)的个体常常难以找到开具丁丙诺啡处方的医生。许多医生没有开具丁丙诺啡的豁免权,而且很大一部分获得豁免权的医生也没有满负荷开具处方。本研究旨在定量了解医生为何不更频繁地使用丁丙诺啡治疗OUD。

方法

对有和没有开具丁丙诺啡豁免权的医生(n = 558)进行了调查,询问他们对开具丁丙诺啡相关缺点的看法。此外,还确定了能鼓励没有豁免权的医生获得豁免权以及能鼓励有豁免权的医生接纳更多新患者的资源。该调查于2016年春/夏通过美国成瘾医学协会和美国医学协会的邮件列表在线分发给医生。

结果与结论

采用逻辑回归分析来确定受访者表示不愿意增加处方量的原因(χ(4)=73.18,p<0.001);主要原因是对激动剂治疗缺乏信心(比值比3.98,95%置信区间,1.43至11.1,p = 0.008)、没有时间接待更多患者(比值比5.54,95%置信区间,3.5至8.7,p<0.001)以及认为报销率不足(比值比2.50,95%置信区间,1.3至4.8,p = 0.006)。还讨论了未获得豁免权和获得豁免权的医生在对丁丙诺啡治疗的态度以及会增加开具处方意愿的资源方面的差异。确定丁丙诺啡使用的障碍对于扩大OUD患者的治疗选择至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ea6/5524453/bcdd444d88b4/nihms870270f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ea6/5524453/bcdd444d88b4/nihms870270f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ea6/5524453/bcdd444d88b4/nihms870270f1.jpg

相似文献

1
Why aren't physicians prescribing more buprenorphine?为什么医生没有开出更多的丁丙诺啡?
J Subst Abuse Treat. 2017 Jul;78:1-7. doi: 10.1016/j.jsat.2017.04.005. Epub 2017 Apr 12.
2
Characteristics and prescribing practices of clinicians recently waivered to prescribe buprenorphine for the treatment of opioid use disorder.最近获准开具丁丙诺啡用于治疗阿片类药物使用障碍的临床医生的特征和处方实践。
Addiction. 2019 Mar;114(3):471-482. doi: 10.1111/add.14436. Epub 2018 Oct 15.
3
Prescribing Practices of Rural Physicians Waivered to Prescribe Buprenorphine.农村医生开具丁丙诺啡处方的规定豁免。
Am J Prev Med. 2018 Jun;54(6 Suppl 3):S208-S214. doi: 10.1016/j.amepre.2018.02.006.
4
Prescribing patterns of buprenorphine waivered physicians.有资格开丁丙诺啡的医师的处方模式。
Drug Alcohol Depend. 2017 Dec 1;181:213-218. doi: 10.1016/j.drugalcdep.2017.10.002. Epub 2017 Oct 18.
5
Association of Buprenorphine-Waivered Physician Supply With Buprenorphine Treatment Use and Prescription Opioid Use in Medicaid Enrollees.美沙酮处方医师人数与医疗补助计划参保者美沙酮治疗使用和处方类阿片药物使用的关联。
JAMA Netw Open. 2018 Sep 7;1(5):e182943. doi: 10.1001/jamanetworkopen.2018.2943.
6
Overcoming Barriers to Prescribing Buprenorphine for the Treatment of Opioid Use Disorder: Recommendations from Rural Physicians.克服开具丁丙诺啡用于治疗阿片类药物使用障碍的障碍:农村医生的建议。
J Rural Health. 2019 Jan;35(1):113-121. doi: 10.1111/jrh.12328. Epub 2018 Oct 19.
7
Attitudinal barriers to buprenorphine prescription and former waiver training.阿片类物质使用障碍患者对丁丙诺啡处方和先前豁免培训的态度障碍。
J Opioid Manag. 2024 Jul-Aug;20(4):339-346. doi: 10.5055/jom.0827.
8
Prescribing Practices of Nurse Practitioners and Physician Assistants Waivered to Prescribe Buprenorphine and the Barriers They Experience Prescribing Buprenorphine.护士从业者和医师助理的处方实践,以及他们在开具丁丙诺啡处方时所经历的障碍。
J Rural Health. 2020 Mar;36(2):187-195. doi: 10.1111/jrh.12404. Epub 2019 Oct 25.
9
Primary care physicians' preparedness to treat opioid use disorder in the United States: A cross-sectional survey.美国初级保健医生治疗阿片类药物使用障碍的准备情况:一项横断面调查。
Drug Alcohol Depend. 2021 Aug 1;225:108811. doi: 10.1016/j.drugalcdep.2021.108811. Epub 2021 Jun 18.
10
Survey of Barriers and Facilitators to Prescribing Buprenorphine and Clinician Perceptions on the Drug Addiction Treatment Act of 2000 Waiver.《2000 年《药物成瘾治疗法》豁免:开处丁丙诺啡的障碍和促进因素调查及临床医生认知》
JAMA Netw Open. 2022 May 2;5(5):e2212419. doi: 10.1001/jamanetworkopen.2022.12419.

引用本文的文献

1
Assessing buprenorphine treatment utilization and SAMHSA DATA waiver provider distribution in 2021: a real-world analysis in California.评估2021年丁丙诺啡治疗的使用情况以及美国药物滥用和精神健康服务管理局(SAMHSA)数据豁免提供者的分布:加利福尼亚州的一项真实世界分析。
Sci Rep. 2025 Aug 9;15(1):29168. doi: 10.1038/s41598-025-07315-9.
2
A learning health system model for addressing substance use: Denver Health Center for Addiction Medicine.一种用于解决药物使用问题的学习型健康系统模型:丹佛健康成瘾医学中心。
Learn Health Syst. 2025 Mar 27;9(3):e70003. doi: 10.1002/lrh2.70003. eCollection 2025 Jul.
3
Clinical Decision Support System for Primary Care of Opioid Use Disorder: A Randomized Clinical Trial.

本文引用的文献

1
Buprenorphine prescribing practice trends and attitudes among New York providers.纽约医疗服务提供者丁丙诺啡的处方开具实践趋势及态度
J Subst Abuse Treat. 2017 Mar;74:1-6. doi: 10.1016/j.jsat.2016.10.005. Epub 2016 Oct 29.
2
Treatment of Opioid-Use Disorders.阿片类物质使用障碍的治疗
N Engl J Med. 2016 Jul 28;375(4):357-68. doi: 10.1056/NEJMra1604339.
3
Should the United States Government Repeal Restrictions on Buprenorphine/Naloxone Treatment?美国政府应该废除对丁丙诺啡/纳洛酮治疗的限制吗?
阿片类物质使用障碍基层医疗临床决策支持系统:一项随机临床试验
JAMA Intern Med. 2025 Jul 14. doi: 10.1001/jamainternmed.2025.2535.
4
Implementing buprenorphine for opioid use disorder in veterans health administration primary care: a qualitative analysis.在退伍军人健康管理局初级保健中实施丁丙诺啡治疗阿片类药物使用障碍:一项定性分析。
Addict Sci Clin Pract. 2025 Apr 30;20(1):38. doi: 10.1186/s13722-025-00568-9.
5
Quantifying the size and characteristics of a population of people who use drugs on the reservation lands of a tribal nation in the southern plains (USA).对美国南部平原一个部落国家保留地内吸毒人群的规模和特征进行量化。
Harm Reduct J. 2025 Apr 4;22(1):48. doi: 10.1186/s12954-025-01194-z.
6
Comfort in Providing Care and Associations With Attitudes Towards Substance Use: A Survey of Mental Health Clinicians at an Urban Hospital in Vancouver, Canada.提供护理时的舒适度以及与物质使用态度的关联:对加拿大温哥华一家城市医院心理健康临床医生的调查
J Psychiatr Ment Health Nurs. 2025 Jun;32(3):774-782. doi: 10.1111/jpm.13152. Epub 2025 Feb 14.
7
Evidence-informed language: interpretation and impact on intentions to treat - results of an online survey of medical students and specialists in German-speaking countries.循证语言:解释及其对治疗意向的影响——对德语国家医学生和专家的在线调查结果
BMJ Open. 2025 Feb 7;15(2):e082907. doi: 10.1136/bmjopen-2023-082907.
8
The Implementation Climate for Integrating Buprenorphine Prescribing into Rural Primary Care.将丁丙诺啡处方纳入农村初级保健的实施环境
J Gen Intern Med. 2024 Dec 12. doi: 10.1007/s11606-024-09260-1.
9
Patient and provider experiences with opioid use disorder care delivered via telehealth: A systematic mixed-studies review.患者和提供者通过远程医疗接受阿片类物质使用障碍护理的体验:一项系统的混合研究综述。
Drug Alcohol Depend. 2025 Jan 1;266:112522. doi: 10.1016/j.drugalcdep.2024.112522. Epub 2024 Dec 4.
10
Impact of COVID-19 Pandemic on Emergency Department Visits for Opioid Use Disorder Across University of California Health Centers.2019年冠状病毒病大流行对加州大学健康中心阿片类药物使用障碍患者急诊就诊情况的影响
West J Emerg Med. 2024 Nov;25(6):883-889. doi: 10.5811/westjem.18468.
Subst Use Misuse. 2016 Oct 14;51(12):1674-1679. doi: 10.1080/10826084.2016.1200097. Epub 2016 Jul 27.
4
Using a Learning Collaborative Strategy With Office-based Practices to Increase Access and Improve Quality of Care for Patients With Opioid Use Disorders.采用基于办公室实践的学习协作策略,以增加阿片类药物使用障碍患者获得医疗服务的机会并提高医疗质量。
J Addict Med. 2016 Mar-Apr;10(2):117-23. doi: 10.1097/ADM.0000000000000200.
5
Relationship between Nonmedical Prescription-Opioid Use and Heroin Use.非医疗处方阿片类药物使用与海洛因使用之间的关系。
N Engl J Med. 2016 Jan 14;374(2):154-63. doi: 10.1056/NEJMra1508490.
6
Using Telemedicine Technology to Assess Physician Outpatient Teaching.利用远程医疗技术评估医生门诊教学。
Fam Med. 2015 Nov-Dec;47(10):807-10.
7
States' implementation of the Affordable Care Act and the supply of physicians waivered to prescribe buprenorphine for opioid dependence.各州对《平价医疗法案》的实施以及开具丁丙诺啡治疗阿片类药物依赖的医生供应情况有所波动。
Drug Alcohol Depend. 2015 Dec 1;157:36-43. doi: 10.1016/j.drugalcdep.2015.09.032. Epub 2015 Oct 9.
8
Buprenorphine Prescribing Availability in a Sample of Ohio Specialty Treatment Organizations.俄亥俄州专科治疗机构样本中丁丙诺啡的处方可得性
J Addict Behav Ther Rehabil. 2015;4(2). doi: 10.4172/2324-9005.1000140.
9
Where Is Buprenorphine Dispensed to Treat Opioid Use Disorders? The Role of Private Offices, Opioid Treatment Programs, and Substance Abuse Treatment Facilities in Urban and Rural Counties.用于治疗阿片类药物使用障碍的丁丙诺啡在哪里配发?私人诊所、阿片类药物治疗项目以及城乡县的药物滥用治疗设施所起的作用。
Milbank Q. 2015 Sep;93(3):561-83. doi: 10.1111/1468-0009.12137.
10
Medical teleconsultation to general practitioners reduces the medical error vulnerability of internal medicine patients.面向全科医生的医学远程会诊降低了内科患者出现医疗差错的可能性。
Eur J Intern Med. 2015 Nov;26(9):675-9. doi: 10.1016/j.ejim.2015.08.010. Epub 2015 Aug 30.