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为什么医生没有开出更多的丁丙诺啡?

Why aren't physicians prescribing more buprenorphine?

作者信息

Huhn Andrew S, Dunn Kelly E

机构信息

Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

出版信息

J Subst Abuse Treat. 2017 Jul;78:1-7. doi: 10.1016/j.jsat.2017.04.005. Epub 2017 Apr 12.

Abstract

BACKGROUND & OBJECTIVE: Buprenorphine is an underutilized pharmacotherapy that can play a key role in combating the opioid epidemic. Individuals with opioid use disorder (OUD) often struggle to find physicians that prescribe buprenorphine. Many physicians do not have the waiver to prescribe buprenorphine, and a large proportion of physicians that are waivered do not prescribe to capacity. This study aimed to quantitatively understand why physicians do not utilize buprenorphine for the treatment of OUD more frequently.

METHODS

Physicians (n=558) with and without the waiver to prescribe buprenorphine were surveyed about perceived drawbacks associated with prescribing buprenorphine. Furthermore, resources were identified that would encourage those without the waiver to obtain it, and those with the waiver to accept more new patients. The survey was distributed online to physicians in the spring/summer of 2016 via the American Society for Addiction Medicine and American Medical Association listservs.

RESULTS AND CONCLUSIONS

A logistic regression analysis was used to identify reasons that respondents indicated no willingness to increase prescribing (χ(4)=73.18, p<0.001); main reasons were lack of belief in agonist treatment (OR 3.98, 95% CI, 1.43 to 11.1, p=0.008), lack of time for additional patients (OR 5.54, 95% CI, 3.5 to 8.7, p<0.001), and belief that reimbursement rates are insufficient (OR 2.50, 95% CI, 1.3 to 4.8, p=0.006). Differences between non-waivered and waivered physicians concerning attitudes toward buprenorphine treatment as well as resources that would increase willingness to prescribe are also discussed. Identifying barriers to buprenorphine utilization is crucial in expanding treatment options for individuals with OUD.

摘要

背景与目的

丁丙诺啡是一种未得到充分利用的药物疗法,在对抗阿片类药物流行方面可发挥关键作用。患有阿片类药物使用障碍(OUD)的个体常常难以找到开具丁丙诺啡处方的医生。许多医生没有开具丁丙诺啡的豁免权,而且很大一部分获得豁免权的医生也没有满负荷开具处方。本研究旨在定量了解医生为何不更频繁地使用丁丙诺啡治疗OUD。

方法

对有和没有开具丁丙诺啡豁免权的医生(n = 558)进行了调查,询问他们对开具丁丙诺啡相关缺点的看法。此外,还确定了能鼓励没有豁免权的医生获得豁免权以及能鼓励有豁免权的医生接纳更多新患者的资源。该调查于2016年春/夏通过美国成瘾医学协会和美国医学协会的邮件列表在线分发给医生。

结果与结论

采用逻辑回归分析来确定受访者表示不愿意增加处方量的原因(χ(4)=73.18,p<0.001);主要原因是对激动剂治疗缺乏信心(比值比3.98,95%置信区间,1.43至11.1,p = 0.008)、没有时间接待更多患者(比值比5.54,95%置信区间,3.5至8.7,p<0.001)以及认为报销率不足(比值比2.50,95%置信区间,1.3至4.8,p = 0.006)。还讨论了未获得豁免权和获得豁免权的医生在对丁丙诺啡治疗的态度以及会增加开具处方意愿的资源方面的差异。确定丁丙诺啡使用的障碍对于扩大OUD患者的治疗选择至关重要。

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