Neil J C, Fulton R, McFarlane R, Rigby M, Stewart M, Terry A, Tzavaras T
Beatson Institute for Cancer Research, Bearsden, Glasgow, UK.
Br J Cancer Suppl. 1988 Dec;9:76-9.
The discovery of the first example of retroviral transduction of an immunological effector molecule has led us to reconsider the possible importance of cell surface receptors of the immune system in leukaemia development. Antigen receptors on lymphoid cells not only bind external ligands but are crucial in the control of cellular proliferation. The concept of autocrine stimulation in oncogenesis is already well established and we see no reason to exclude the possibility of analogous mechanism operating through antigen receptors. At present, we are investigating the oncogenic function of the retrovirus (FeLV-T17) carrying a T-cell receptor gene (v-tcr). In addressing the general concept of oncogenesis by ligand/receptor interactions in the immune system we face the problem of the diversity and, for T-cell antigen receptors, the complex nature of receptor-ligand interaction. Nevertheless, the implications of the model encourage us to continue to search for new experimental tools and approaches to the question.
逆转录病毒转导免疫效应分子首个实例的发现，促使我们重新思考免疫系统细胞表面受体在白血病发展中可能具有的重要性。淋巴细胞上的抗原受体不仅能结合细胞外配体，在控制细胞增殖方面也至关重要。肿瘤发生中的自分泌刺激概念已得到充分确立，我们认为没有理由排除通过抗原受体发挥类似机制的可能性。目前，我们正在研究携带T细胞受体基因（v-tcr）的逆转录病毒（FeLV-T17）的致癌功能。在探讨免疫系统中通过配体/受体相互作用导致肿瘤发生的一般概念时，我们面临着多样性问题，对于T细胞抗原受体而言，还面临受体-配体相互作用的复杂性问题。尽管如此，该模型的启示鼓励我们继续寻找针对这一问题的新实验工具和方法。
