Antwi Aaron Opoku, Obiri David Darko, Osafo Newman
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science & Technology (KNUST), Kumasi, Ghana.
Mediators Inflamm. 2017;2017:2953930. doi: 10.1155/2017/2953930. Epub 2017 May 5.
We explored the potential benefits of stigmasterol in the treatment of asthma, an airway disorder characterized by immune pathophysiology and with an ever-increasing worldwide prevalence. We assessed the modulatory effect of the intraperitoneal administration of stigmasterol on experimentally induced airway inflammation in guinea pigs. The effect of stigmasterol on inflammatory cell proliferation, oxidative stress, lung histopathology, and remodeling was investigated. The results showed significant suppressive effects on ovalbumin-induced airway inflammatory damage. Stigmasterol at 10-100 mg/kg reduced proliferation of eosinophils, lymphocytes, and monocytes while reducing peribronchiolar, perivascular, and alveolar infiltration of inflammatory cells. Histopathology revealed stigmasterol maintained lung architecture and reversed collagen deposition, an index of lung remodeling. Overexpression of serum vascular cell adhesion molecule-1 (VCAM-1) and ovalbumin-specific immunoglobulin E (OVA sIgE) elicited by ovalbumin sensitization and challenge was significantly controlled with stigmasterol. Taken together, stigmasterol possessed significant antiasthmatic properties and had suppressive effects on key features of allergen-induced asthma.
我们探究了豆甾醇在治疗哮喘方面的潜在益处，哮喘是一种以免疫病理生理学为特征且在全球范围内患病率不断上升的气道疾病。我们评估了腹腔注射豆甾醇对豚鼠实验性诱导气道炎症的调节作用。研究了豆甾醇对炎症细胞增殖、氧化应激、肺组织病理学和重塑的影响。结果显示对卵清蛋白诱导的气道炎症损伤有显著的抑制作用。10 - 100毫克/千克的豆甾醇可减少嗜酸性粒细胞、淋巴细胞和单核细胞的增殖，同时减少支气管周围、血管周围和肺泡的炎症细胞浸润。组织病理学显示豆甾醇维持了肺结构并逆转了胶原沉积，这是肺重塑的一个指标。豆甾醇显著控制了由卵清蛋白致敏和激发引起的血清血管细胞黏附分子-1（VCAM - 1）和卵清蛋白特异性免疫球蛋白E（OVA sIgE）的过表达。综上所述，豆甾醇具有显著的抗哮喘特性，对变应原诱导哮喘的关键特征具有抑制作用。
