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Amyloid β Modification: A Key to the Sporadic Alzheimer's Disease?

作者信息

Barykin Evgeny P, Mitkevich Vladimir A, Kozin Sergey A, Makarov Alexander A

机构信息

Engelhardt Institute of Molecular Biology, Russian Academy of SciencesMoscow, Russia.

出版信息

Front Genet. 2017 May 15;8:58. doi: 10.3389/fgene.2017.00058. eCollection 2017.

DOI:10.3389/fgene.2017.00058
PMID:28555154
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5430028/
Abstract
摘要

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Genomic variants, genes, and pathways of Alzheimer's disease: An overview.阿尔茨海默病的基因组变异、基因及信号通路概述
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[Isomerization of Asp7 increases the toxic effects of amyloid β and its phosphorylated form in SH-SY5Y neuroblastoma cells].[天冬氨酸7的异构化增加了淀粉样蛋白β及其磷酸化形式对SH-SY5Y神经母细胞瘤细胞的毒性作用]
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4-Hydroxynonenal (HNE) modified proteins in metabolic diseases.
一种针对淀粉样β寡聚体结合剂的基因编码筛选方法。
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Survey of the Aβ-peptide structural diversity: molecular dynamics approaches.Aβ 肽结构多样性研究：分子动力学方法
Biophys Rev. 2024 Nov 20;16(6):701-722. doi: 10.1007/s12551-024-01253-y. eCollection 2024 Dec.
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APP lysine 612 lactylation ameliorates amyloid pathology and memory decline in Alzheimer's disease.淀粉样前体蛋白（APP）赖氨酸612位点的乳酰化改善阿尔茨海默病中的淀粉样病理和记忆衰退。
J Clin Invest. 2025 Jan 2;135(1):e184656. doi: 10.1172/JCI184656.
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Beta-Amyloid and Its Asp7 Isoform: Morphological and Aggregation Properties and Effects of Intracerebroventricular Administration.β-淀粉样蛋白及其Asp7亚型：形态学、聚集特性及脑室内注射的影响
Brain Sci. 2024 Oct 21;14(10):1042. doi: 10.3390/brainsci14101042.
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Determination of Potential Lead Compound from for Alzheimer's Disease through Pharmacokinetic Prediction, Molecular Docking, Dynamic Simulation, and Experimental Validation.基于药代动力学预测、分子对接、动态模拟和实验验证从 中确定阿尔茨海默病的潜在先导化合物。
Int J Mol Sci. 2024 Sep 29;25(19):10507. doi: 10.3390/ijms251910507.
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β-Amyloids and Immune Responses Associated with Alzheimer's Disease.β-淀粉样蛋白与阿尔茨海默病相关的免疫反应。
Cells. 2024 Sep 28;13(19):1624. doi: 10.3390/cells13191624.
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Toward the development of a sporadic model of Alzheimer's disease: comparing pathologies between humanized APP and the familial J20 mouse models.迈向阿尔茨海默病散发性模型的开发：比较人源化APP小鼠模型与家族性J20小鼠模型的病理学特征
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Cell Death Dis. 2024 May 13;15(5):331. doi: 10.1038/s41419-024-06662-1.
代谢疾病中 4-羟基壬烯醛（HNE）修饰的蛋白质。
Free Radic Biol Med. 2017 Oct;111:309-315. doi: 10.1016/j.freeradbiomed.2016.10.497. Epub 2016 Nov 1.
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Citrullination and deamidation affect aggregation properties of amyloid β-proteins.瓜氨酸化和脱酰胺作用影响β-淀粉样蛋白的聚集特性。
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The Evolution of Genetics: Alzheimer's and Parkinson's Diseases.遗传学的演变：阿尔茨海默病与帕金森病
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Aging is associated with dimerization and inactivation of the brain-enriched tyrosine phosphatase STEP.衰老与大脑富集的酪氨酸磷酸酶STEP的二聚化和失活有关。
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The amyloid hypothesis of Alzheimer's disease at 25 years.阿尔茨海默病淀粉样蛋白假说25年回顾
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Common Polymorphisms Within QPCT Gene Are Associated with the Susceptibility of Schizophrenia in a Han Chinese Population.常见的 QPCT 基因多态性与汉族人群精神分裂症易感性相关。
Mol Neurobiol. 2016 Nov;53(9):6362-6366. doi: 10.1007/s12035-015-9541-3. Epub 2015 Nov 16.
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Three dimensions of the amyloid hypothesis: time, space and 'wingmen'.淀粉样蛋白假说的三个维度：时间、空间与“帮手”
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