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接受化疗或造血干细胞移植的儿童的中枢神经系统并发症

Central Nervous System Complications in Children Receiving Chemotherapy or Hematopoietic Stem Cell Transplantation.

作者信息

Cordelli Duccio Maria, Masetti Riccardo, Zama Daniele, Toni Francesco, Castelli Ilaria, Ricci Emilia, Franzoni Emilio, Pession Andrea

机构信息

Child Neurology and Psychiatry Unit, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.

Department of Pediatrics, "Lalla Seràgnoli", Hematology-Oncology Unit, University of Bologna, Bologna, Italy.

出版信息

Front Pediatr. 2017 May 15;5:105. doi: 10.3389/fped.2017.00105. eCollection 2017.

DOI:10.3389/fped.2017.00105
PMID:28555178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5430164/
Abstract

Therapy-related neurotoxicity greatly affects possibility of survival and quality of life of pediatric patients treated for cancer. Central nervous system (CNS) involvement is heterogeneous, varying from very mild and transient symptoms to extremely severe and debilitating, or even lethal syndromes. In this review, we will discuss the broad scenario of CNS complications and toxicities occurring during the treatment of pediatric patients receiving both chemotherapies and hematopoietic stem cell transplantation. Different types of complications are reviewed ranging from therapy related to cerebrovascular with a specific focus on neuroradiologic and clinical features.

摘要

与治疗相关的神经毒性极大地影响了接受癌症治疗的儿科患者的生存可能性和生活质量。中枢神经系统（CNS）受累情况各异，从非常轻微和短暂的症状到极其严重、使人衰弱甚至致命的综合征。在本综述中，我们将讨论接受化疗和造血干细胞移植的儿科患者治疗期间发生的中枢神经系统并发症和毒性的广泛情况。我们将综述不同类型的并发症，从与脑血管相关的治疗，特别关注神经放射学和临床特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0920/5430164/ab991e092b99/fped-05-00105-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0920/5430164/2065ce48b02d/fped-05-00105-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0920/5430164/311bbad4e068/fped-05-00105-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0920/5430164/05f4dfe669b2/fped-05-00105-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0920/5430164/47b13922671a/fped-05-00105-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0920/5430164/ab991e092b99/fped-05-00105-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0920/5430164/2065ce48b02d/fped-05-00105-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0920/5430164/311bbad4e068/fped-05-00105-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0920/5430164/05f4dfe669b2/fped-05-00105-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0920/5430164/47b13922671a/fped-05-00105-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0920/5430164/ab991e092b99/fped-05-00105-g005.jpg

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