Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, China.
Department of Geriatrics and Shandong Key Laboratory of Proteomics, Qilu Hospital of Shandong University, 107 Wenhuaxi, Road, Jinan, Shandong Province, 250012, China.
Neurotox Res. 2017 Oct;32(3):420-425. doi: 10.1007/s12640-017-9754-5. Epub 2017 May 30.
Several studies investigated the prognostic role of copeptin in stroke. The aim of this study is to assess copeptin levels in serum, and investigate their associations with risk of recurrent stroke in a 1-year follow-up study in patients with ischemic stroke. In this post hoc analysis, serum levels of copeptin and NIH stroke scale (NIHSS) were measured at the time of admission in a cohort of 316 patients with ischemic stroke. The end point was stroke recurrence after 1-year follow-up. We used logistic regression model to assess the relationship between copeptin levels and risk recurrent stroke. Logistic regression analysis considering traditional risk factors showed a relationship between serum copeptin levels and moderate-to-high clinical severity when serum copeptin was used as a continuous variable (OR, 1.05; 95% CI, 1.03-1.09). In the follow-up, 54 patients (17.1%) had a stroke recurrence. The stroke recurrence events distribution across the copeptin quartiles ranged between 5.1% (first quartile) to 23.1% (fourth quartile). In multivariate models comparing the third (OR = 2.78; 95% CI 1.85-3.53) and fourth quartiles (OR = 4.00; 95% CI 2.86-6.50) against the first quartile of the copeptin, levels of copeptin were associated with stroke recurrence events. A higher serum copeptin level is a predictor of both severity at admission and stroke recurrence at 1-year in stroke patients.
多项研究探讨了 copeptin 在中风中的预后作用。本研究旨在评估血清 copeptin 水平，并在缺血性中风患者的 1 年随访研究中，调查其与复发性中风风险的相关性。在这项事后分析中，在 316 例缺血性中风患者的队列中，在入院时测量了血清 copeptin 和 NIH 中风量表 (NIHSS) 的水平。终点是 1 年后中风复发。我们使用逻辑回归模型来评估 copeptin 水平与复发性中风风险之间的关系。考虑传统危险因素的逻辑回归分析显示，当将血清 copeptin 用作连续变量时，血清 copeptin 水平与中度至高度临床严重程度之间存在关系（OR，1.05；95%CI，1.03-1.09）。在随访中，有 54 例患者（17.1%）发生了中风复发。在 copeptin 四分位数中，中风复发事件的分布范围从第 1 四分位数的 5.1%到第 4 四分位数的 23.1%。在比较第 3 四分位数（OR=2.78；95%CI 1.85-3.53）和第 4 四分位数（OR=4.00；95%CI 2.86-6.50）与 copeptin 第 1 四分位数的多变量模型中，copeptin 水平与中风复发事件相关。较高的血清 copeptin 水平是入院时严重程度和中风后 1 年中风复发的预测因子。
