Zajdela A, De LaRiva L S, Ghossein N A
Acta Cytol. 1979 Jan-Feb;23(1):75-80.
Nuclear diameters of breast cancer cells obtained by aspiration cytology from 245 patients were measured by ocular micrometry. The nuclei of 50 benign lesions were also measured. Cancers with 80% or more of their nuclei larger than 12 mu were classified as "large nuclear type" (LN). Those with nuclei of 12 mu or less were considered "small nuclear type" (SN). One hundred forty-nine cases of the former and 96 of the latter were evaluated. There was significant overlap in nuclear diameter of benign lesions and SN cancers but minimal overlap between SN and LN cancers. Thirty-eight percent of SN cancers were staged as T1 as compared to only 20% of LN tumors. Survival, free of disease, at five years was 90% for the SN cancers and 58% for the LN cancers (p less than 0.001). Intervals between completion of treatment, appearance of metastases and death were longer for patients with SN cancers. Measurement of nuclear diameters of cells obtained by aspiration cytology may, therefore, be useful in determining the prognosis.
通过目镜测微法测量了245例患者经针吸细胞学检查获取的乳腺癌细胞核直径。还测量了50例良性病变的细胞核直径。细胞核80%或更多大于12微米的癌症被分类为“大核型”（LN）。细胞核为12微米或更小的癌症被视为“小核型”（SN）。对前者149例和后者96例进行了评估。良性病变与SN癌症的核直径有显著重叠，但SN与LN癌症之间的重叠最小。SN癌症中38%分期为T1，而LN肿瘤仅为20%。SN癌症患者5年无病生存率为90%，LN癌症为58%（p<0.001）。SN癌症患者从治疗结束到出现转移和死亡的间隔时间更长。因此，通过针吸细胞学检查获取的细胞的核直径测量可能有助于判断预后。
