Schöndorf H, Naujoks H
J Cancer Res Clin Oncol. 1985;109(3):241-4. doi: 10.1007/BF00390363.
In view of the great variation in the size of epithelial cell nuclei in benign changes in the mammary gland, the cytologist is often faced with diagnostic difficulties. Clear differences in the size of the nuclei in aspiration biopsies from the mammary glands of pregnant women and those from the mammary glands of post-menopausal women seem to indicate that even in normal, unchanged mammary gland epithelia, the cell nuclei size varies in accordance with the hormonal situation and any functional changes that might have occurred. To test these findings, the nuclear area of the mammary gland epithelia was compared in four groups consisting of 20 post-menopausal women, 20 sexually mature women, 20 gravid women and 20 women taking ovulation inhibitors. In addition, we measured the nuclear area of tumour cell nuclei from solidly growing mammary carcinomas and their hybrid forms. The 40 patients with mammary carcinomas included 20 sexually mature women and 20 post-menopausal women. A comparison of the size of the nuclei of normal epithelial cells revealed distinct differences in each group. The only exceptions were the sexually mature women and the women taking ovulation inhibitors, between whom there was no significant difference. The average nuclear area in post-menopausal women was 48 micron 2, in sexually mature women 75 micron 2, in pregnant women 118 micron 2, and in women taking ovulation inhibitors 79 micron 2. The difference between the size of the nuclei in the tumour cells and those in normal mammary gland epithelia was significant in all groups. The average size of the tumour cell nuclei in sexually mature women was 185 micron 2, and in post-menopausal women 170 micron 2. A major difference between the two tumour groups was the noticeably larger range in the size of the nuclear area in the sexually mature women.
鉴于乳腺良性病变中上皮细胞核大小差异很大，细胞学家常常面临诊断困难。孕妇乳腺穿刺活检细胞核大小与绝经后妇女乳腺穿刺活检细胞核大小存在明显差异，这似乎表明，即使在正常、未发生变化的乳腺上皮中，细胞核大小也会根据激素状况以及可能发生的任何功能变化而有所不同。为了验证这些发现，我们对四组女性的乳腺上皮细胞核面积进行了比较，这四组分别为20名绝经后女性、20名性成熟女性、20名孕妇和20名服用排卵抑制剂的女性。此外，我们还测量了实性生长的乳腺癌及其混合形式肿瘤细胞核的面积。40例乳腺癌患者包括20名性成熟女性和20名绝经后女性。对正常上皮细胞核大小的比较显示，每组之间存在明显差异。唯一的例外是性成熟女性和服用排卵抑制剂的女性，她们之间没有显著差异。绝经后女性的平均核面积为48平方微米，性成熟女性为75平方微米，孕妇为118平方微米，服用排卵抑制剂的女性为79平方微米。在所有组中，肿瘤细胞核大小与正常乳腺上皮细胞核大小之间的差异均具有显著性。性成熟女性肿瘤细胞核的平均大小为185平方微米，绝经后女性为170平方微米。两组肿瘤之间的一个主要差异是，性成熟女性细胞核面积大小的范围明显更大。
