Cheng Tina L, Bogue Clifford W, Dover George J
Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland;
Department of Population, Family and Reproductive Health, Bloomberg School of Public Health, Baltimore, Maryland; and.
Pediatrics. 2017 May;139(5). doi: 10.1542/peds.2016-3803.
The "7 Great Achievements in Pediatric Research" campaign noted discoveries in the past 40 years that have improved child and adult health in the United States and around the globe. This article predicts the next 7 great pediatric research advancements, including new immunizations, cancer immunotherapy, genomic discoveries, identification of early antecedents of adult health, impact of specific social-environmental influences on biology and health, quality improvement science, and implementation and dissemination research to reduce global poverty. It is an extraordinary time of new research tools that include electronic health records, technological ability to manage big data and measure "omics," and new functional and structural imaging modalities. These tools will discern mechanisms leading to health and disease with new prevention targets and cures. This article further discusses the challenges and opportunities to accelerate these exciting pediatric research discoveries to improve the lives of children and the adults they will become.
“儿科研究七大成就”活动列举了过去40年中在美国及全球改善儿童和成人健康状况的各项发现。本文预测了未来儿科研究的七大进展，包括新型疫苗接种、癌症免疫疗法、基因组学发现、成人健康早期先兆的识别、特定社会环境因素对生物学和健康的影响、质量改进科学，以及为减少全球贫困而开展的实施与传播研究。当下正处于一个拥有诸多新型研究工具的非凡时代，这些工具包括电子健康记录、管理大数据和测量“组学”的技术能力，以及新的功能和结构成像模式。这些工具将揭示导致健康和疾病的机制，并带来新的预防靶点和治疗方法。本文还进一步探讨了加速这些令人振奋的儿科研究发现以改善儿童及其未来成年生活的挑战与机遇。
