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ω-3和ω-6脂肪酸代谢酶在结直肠癌中的差异表达及其预后意义。

The differential expression of omega-3 and omega-6 fatty acid metabolising enzymes in colorectal cancer and its prognostic significance.

作者信息

Alnabulsi Abdo, Swan Rebecca, Cash Beatriz, Alnabulsi Ayham, Murray Graeme I

机构信息

Department of Pathology, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen AB25, 2ZD, UK.

Vertebrate Antibodies, Zoology Building, Tillydrone Avenue, Aberdeen AB24 2TZ, UK.

出版信息

Br J Cancer. 2017 Jun 6;116(12):1612-1620. doi: 10.1038/bjc.2017.135. Epub 2017 May 30.

DOI:10.1038/bjc.2017.135
PMID:28557975
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5518862/
Abstract

BACKGROUND

Colorectal cancer is a common malignancy and one of the leading causes of cancer-related deaths. The metabolism of omega fatty acids has been implicated in tumour growth and metastasis.

METHODS

This study has characterised the expression of omega fatty acid metabolising enzymes CYP4A11, CYP4F11, CYP4V2 and CYP4Z1 using monoclonal antibodies we have developed. Immunohistochemistry was performed on a tissue microarray containing 650 primary colorectal cancers, 285 lymph node metastasis and 50 normal colonic mucosa.

RESULTS

The differential expression of CYP4A11 and CYP4F11 showed a strong association with survival in both the whole patient cohort (hazard ratio (HR)=1.203, 95% CI=1.092-1.324, χ=14.968, P=0.001) and in mismatch repair-proficient tumours (HR=1.276, 95% CI=1.095-1.488, χ=9.988, P=0.007). Multivariate analysis revealed that the differential expression of CYP4A11 and CYP4F11 was independently prognostic in both the whole patient cohort (P=0.019) and in mismatch repair proficient tumours (P=0.046).

CONCLUSIONS

A significant and independent association has been identified between overall survival and the differential expression of CYP4A11 and CYP4F11 in the whole patient cohort and in mismatch repair-proficient tumours.

摘要

背景

结直肠癌是一种常见的恶性肿瘤，也是癌症相关死亡的主要原因之一。ω脂肪酸的代谢与肿瘤生长和转移有关。

方法

本研究使用我们开发的单克隆抗体对ω脂肪酸代谢酶CYP4A11、CYP4F11、CYP4V2和CYP4Z1的表达进行了表征。对包含650例原发性结直肠癌、285例淋巴结转移和50例正常结肠黏膜的组织芯片进行了免疫组织化学分析。

结果

CYP4A11和CYP4F11的差异表达与整个患者队列（风险比（HR）=1.203，95%置信区间=1.092-1.324，χ=14.968，P=0.001）以及错配修复功能正常的肿瘤（HR=1.276，95%置信区间=1.095-1.488，χ=9.988，P=0.007）的生存率密切相关。多变量分析显示，CYP4A11和CYP4F11的差异表达在整个患者队列（P=0.019）和错配修复功能正常的肿瘤（P=0.046）中均具有独立预后价值。

结论

在整个患者队列以及错配修复功能正常的肿瘤中，已确定总生存期与CYP4A11和CYP4F11的差异表达之间存在显著且独立的关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e08/5518862/741731551197/bjc2017135f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e08/5518862/77727148e908/bjc2017135f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e08/5518862/c087dd443122/bjc2017135f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e08/5518862/741731551197/bjc2017135f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e08/5518862/77727148e908/bjc2017135f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e08/5518862/c087dd443122/bjc2017135f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e08/5518862/741731551197/bjc2017135f3.jpg

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2
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3
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5
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