Gweon Hye Mi, Jeong Joon, Son Eun Ju, Youk Ji Hyun, Kim Jeong-Ah, Ko Kyung Hee
Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
PLoS One. 2017 May 30;12(5):e0178445. doi: 10.1371/journal.pone.0178445. eCollection 2017.
To investigate the significance of accompanying NME in invasive ductal carcinoma (IDC) on preoperative MR imaging and assess the factors affecting the significance.
Between January 2015 and February 2016, 163 consecutive patients with IDC who underwent preoperative MR imaging and subsequent surgery were enrolled and reviewed. Index cancer mass size and total extent with accompanying NME on MR images was measured and compared with pathologic size. Positive NME was defined as pathological result of IDC or DCIS. To identify affecting factors associated with frequency of accompanying NME on MR and positive pathologic result, clinicopathologic features were compared between breast cancers with NME and without NME, and between breast cancers with positive NME and negative NME using the Student t-test or Chi-square test.
Of the 163 invasive breast cancers, 123(75.5%) cancers presented as only mass feature and 40(24.5%) cancers had accompanying NME around the index mass. Of the 40 accompanying NME, 22 (55%) had positive pathologic results and 18 (45%) had negative results. The HER2 positive status was significantly associated with positive pathologic results of accompanying NME (P = .016).
Accompanying NME on preoperative MR imaging showed malignant pathologic results in 55%. The HER2 positive IDC was more frequently accompanied by malignant NME.
探讨浸润性导管癌（IDC）中伴随非肿块强化（NME）在术前磁共振成像（MR）中的意义，并评估影响该意义的因素。
纳入2015年1月至2016年2月期间连续163例行术前MR成像及后续手术的IDC患者并进行回顾性分析。测量MR图像上肿瘤原发灶大小及伴随NME的总体范围，并与病理大小进行比较。NME阳性定义为IDC或导管原位癌（DCIS）的病理结果。为确定与MR上伴随NME频率及病理阳性结果相关的影响因素，采用Student t检验或卡方检验，比较有NME和无NME的乳腺癌之间，以及NME阳性和阴性的乳腺癌之间的临床病理特征。
163例浸润性乳腺癌中，123例（75.5%）仅表现为肿块特征，40例（24.5%）肿瘤原发灶周围伴有NME。40例伴有NME的病例中，22例（55%）病理结果为阳性，18例（45%）为阴性。HER2阳性状态与伴随NME的病理阳性结果显著相关（P = .016）。
术前MR成像中伴随的NME有55%显示为恶性病理结果。HER2阳性的IDC更常伴有恶性NME。
