Li Yiping, Wang Xiaolong, Shen Zhijie
Department of Cardiovascular, Shuguang Hospital Affiliated to Shanghai University of TCMShanghai, China.
Am J Transl Res. 2017 May 15;9(5):2038-2049. eCollection 2017.
Dyslipidemia significantly contributes to the development of cardiovascular disease (CVD), which is the most common cause of morbidity and mortality in China. Statins are the first-line therapy for reducing LDL-C serum levels. However, they have adverse effects, which restrict their clinical application. Traditional Chinese medicine (TCM) preparations have been increasingly described for their beneficial effects in hyperlipidemic patients. Existing data show that the lipid-regulating effects of TCM may be related to: (1) inhibiting intestinal absorption of lipids; (2) reducing endogenous cholesterol synthesis; (3) regulating cholesterol transport; (4) promoting the excretion of cholesterol in the liver; (5) regulating transcription factors related to lipid metabolism. This study provides an overview of recent studies and elaborates the underlying mechanisms of lipid-regulation by TCM.
血脂异常是中国心血管疾病（CVD）发病和死亡的最常见原因，对心血管疾病的发展有显著影响。他汀类药物是降低低密度脂蛋白胆固醇（LDL-C）血清水平的一线治疗药物。然而，它们有不良反应，这限制了它们的临床应用。越来越多的研究表明，中药制剂对高脂血症患者有有益作用。现有数据表明，中药的调脂作用可能与以下方面有关：（1）抑制肠道对脂质的吸收；（2）减少内源性胆固醇合成；（3）调节胆固醇转运；（4）促进肝脏中胆固醇的排泄；（5）调节与脂质代谢相关的转录因子。本研究概述了近期的研究，并阐述了中药调脂的潜在机制。
