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肠道菌群:中药改善脂质代谢紊乱的新靶点。

Intestinal flora: A new target for traditional Chinese medicine to improve lipid metabolism disorders.

作者信息

Liu Min, Shi Wei, Huang Yefang, Wu Yeke, Wu Keming

机构信息

Department of Gynecology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Department of Stomatology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

出版信息

Front Pharmacol. 2023 Mar 1;14:1134430. doi: 10.3389/fphar.2023.1134430. eCollection 2023.

Abstract

Lipid metabolism disorders (LMD) can cause a series of metabolic diseases, including hyperlipidemia, obesity, non-alcoholic fatty liver disease (NAFLD) and atherosclerosis (AS). Its development is caused by more pathogenic factors, among which intestinal flora dysbiosis is considered to be an important pathogenic mechanism of LMD. In recent years, the research on intestinal flora has made great progress, opening up new perspectives on the occurrence and therapeutic effects of diseases. With its complex composition and wide range of targets, traditional Chinese medicine (TCM) is widely used to prevent and treat LMD. This review takes intestinal flora as a target, elaborates on the scientific connotation of TCM in the treatment of LMD, updates the therapeutic thinking of LMD, and provides a reference for clinical diagnosis and treatment.

摘要

脂质代谢紊乱(LMD)可引发一系列代谢性疾病,包括高脂血症、肥胖症、非酒精性脂肪性肝病(NAFLD)和动脉粥样硬化(AS)。其发病由多种致病因素引起,其中肠道菌群失调被认为是LMD的重要致病机制。近年来,对肠道菌群的研究取得了很大进展,为疾病的发生和治疗效果开辟了新的视角。中药(TCM)因其成分复杂、靶点广泛,被广泛用于预防和治疗LMD。本综述以肠道菌群为靶点,阐述了中药治疗LMD的科学内涵,更新了LMD的治疗思路,为临床诊断和治疗提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db49/10014879/5d4f9ab157db/fphar-14-1134430-g001.jpg

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