拉贝洛尔对人体血小板功能的影响。

Effect of labetalol on human platelet function.

Anfossi G, Trovati M, Lanzio M, Mularoni E, Massucco P, Emanuelli G

Cattedra di Clinica Medica III, University of Turin, Italy.

Clin Exp Pharmacol Physiol. 1988 Jun;15(6):437-48. doi: 10.1111/j.1440-1681.1988.tb01099.x.

Abstract

The effects of the alpha-beta-adrenergic antagonist labetalol on the activation of human platelets by adrenaline and other aggregating stimuli have been investigated. 2. Labetalol inhibited platelet aggregation and secretion induced by collagen and the second phase of aggregation caused by ADP, platelet activating factor, adrenaline and ionophore A23187. Adrenaline-induced platelet activation was inhibited by the lowest labetalol concentration. The response to Na arachidonate was minimally affected and the arachidonate-induced thromboxane B2 generation was only partially prevented. 3. The pre-incubation with low concentration of ionophore A23187 overcame labetalol's inhibition of collagen-induced platelet aggregation. 4. Labetalol did not influence intraplatelet cyclic AMP levels. 5. The present investigation provided evidences that the modulation of human platelet function by labetalol could be related also to a decreased Ca2+ availability.

摘要

已研究了α-β肾上腺素能拮抗剂拉贝洛尔对肾上腺素及其他聚集刺激物激活人血小板的作用。2. 拉贝洛尔抑制胶原诱导的血小板聚集和分泌以及ADP、血小板活化因子、肾上腺素和离子载体A23187引起的第二相聚集。最低浓度的拉贝洛尔即可抑制肾上腺素诱导的血小板活化。对花生四烯酸钠的反应受到的影响最小，且花生四烯酸诱导的血栓素B2生成仅被部分阻止。3. 用低浓度离子载体A23187预孵育可克服拉贝洛尔对胶原诱导的血小板聚集的抑制作用。4. 拉贝洛尔不影响血小板内的环磷酸腺苷水平。5. 本研究提供了证据，表明拉贝洛尔对人血小板功能的调节也可能与钙离子可用性降低有关。