Welch M J, Ridgeway P H, Phillpotts R J
Division of Biologics, Centre for Applied Microbiology and Research, Porton Down, Wiltshire, UK.
FEMS Microbiol Immunol. 1988 Dec;1(3):157-62. doi: 10.1111/j.1574-6968.1988.tb02369.x.
Guinea pigs immunised with HSV 1 subunit vaccine were bled, and subsequently challenged intravaginally with HSV 2. The clinical response to virus challenge was quantified, and correlations were sought between clinical score and virus-specific serum antibody titre in functional and binding assays (ELISA, neutralization, complement-mediated cytotoxicity and antibody-dependent cellular cytotoxicity). No significant relationships were found, and it was concluded that reactivity in the serological assays chosen did not correlate with protection against HSV 2 genital infection in vaccinated female guinea pigs.
