雌性豚鼠单纯疱疹病毒生殖器感染作为评估实验性疫苗的模型。
Herpes simplex virus genital infection of the female guinea pig as a model for the evaluation of an experimental vaccine.
作者信息
Thornton B, Baskerville A, Bailey N E, Melling J M, Hambleton P
出版信息
Vaccine. 1984 Jun;2(2):141-8. doi: 10.1016/0264-410x(84)90006-9.
PMID:6099646
Abstract
Substantial protection against herpes simplex type 2 (HSV 2) infection of the female guinea pig genital tract was provided by immunization with an experimental HSV 2 vaccine prepared from the plasma membranes of infected MRC-5 cells. Protection was evaluated in terms of the modification of histopathological lesions and clinical signs and in changes in viral replication and serological responses in vaccinated and control animals.
摘要
用从感染的MRC-5细胞的质膜制备的实验性单纯疱疹病毒2型（HSV 2）疫苗对雌性豚鼠生殖道进行免疫，可提供对HSV 2感染的实质性保护。通过组织病理学损伤和临床症状的改变以及接种疫苗和对照动物的病毒复制和血清学反应的变化来评估保护作用。
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