Ruokonen Hellevi M A, Juurikivi Aino, Kauppila Timo, Heikkinen Anna Maria, Seppänen-Kaijansinkko Riitta
a Department of Oral and Maxillofacial Diseases and Surgery , Head and Neck Center, Helsinki University Hospital , Helsinki , Finland.
b Department of Oral and Maxillofacial Diseases , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.
Acta Odontol Scand. 2017 Aug;75(6):442-445. doi: 10.1080/00016357.2017.1332777. Epub 2017 May 31.
Oral lichen planus (OLP) and lichenoid lesions (OLL) are regarded as precursor lesions of oral squamous cell carcinoma (OSCC) with potential for malignant transformation. This potential is not clear due to difficulties in diagnosis of OLP and OLL. Our aim was therefore to evaluate previously identified OLP and OLL as precursor lesions in OSCC and to identify cancer related etiological factors such as smoking and alcohol consumption.
We retrospectively reviewed all cases (total 323, comprising 164 females and 159 males) with OSCC treated at the Department of Oral and Maxillofacial Diseases and Surgery, Helsinki University Hospital during 2015. Confirmed by histopathological biopsy, 58 (17.9%) had OLP and 13 had OLL (4.0%) as precursor lesion.
Patients with OLP were slightly older than those without it. OLP was more common in females than in males (p < .0001). TN class 1 tumors were more prevalent among patients with OLP or OLL (p = .006) and cancer relapses less common (p = .005). Smoking was less frequent in patients with OLP and OLL (p < .0001). Also alcohol abuse was less frequent among these patients (p < .001).
Our findings confirm the importance of active follow-up of all patients with OLP and OLL even in patients who do not fit a traditional high-risk category for OSCC.
口腔扁平苔藓（OLP）和苔藓样病变（OLL）被视为具有恶性转化潜能的口腔鳞状细胞癌（OSCC）的前驱病变。由于OLP和OLL的诊断困难，这种潜能尚不清楚。因此，我们的目的是评估先前确定的OLP和OLL作为OSCC前驱病变的情况，并确定与癌症相关的病因因素，如吸烟和饮酒。
我们回顾性分析了2015年在赫尔辛基大学医院口腔颌面疾病与外科接受治疗的所有OSCC病例（共323例，其中女性164例，男性159例）。经组织病理学活检确诊，58例（17.9%）有OLP，13例（4.0%）有OLL作为前驱病变。
患有OLP的患者比未患OLP的患者年龄稍大。OLP在女性中比在男性中更常见（p < 0.0001）。TN 1级肿瘤在患有OLP或OLL的患者中更为普遍（p = 0.006），癌症复发较少见（p = 0.005）。OLP和OLL患者吸烟频率较低（p < 0.0001）。这些患者中酒精滥用的频率也较低（p < 0.001）。
我们的研究结果证实，即使对于不符合传统OSCC高风险类别的患者，对所有OLP和OLL患者进行积极随访也很重要。
