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高甘油三酯血症腰围表型与儿童及青少年空腹血糖和血压在一年随访期内的变化

Hypertriglyceridemic Waist Phenotype and Changes in the Fasting Glycemia and Blood Pressure in Children and Adolescents Over One-Year Follow-Up Period.

作者信息

Costa Priscila Ribas de Farias, Assis Ana Marlúcia Oliveira, Cunha Carla de Magalhães, Pereira Emile Miranda, Jesus Gabriela Dos Santos de, Silva Lais Eloy Machado da, Alves Wilanne Pinheiro de Oliveira

机构信息

Universidade Federal da Bahia (UFBA); Salvador, BA - Brazil.

Universidade Federal do Recôncavo da Bahia, Salvador, BA - Brazil.

出版信息

Arq Bras Cardiol. 2017 Jul;109(1):47-53. doi: 10.5935/abc.20170067. Epub 2017 May 25.

Abstract

BACKGROUND

: The hypertriglyceridemic waist (HTW) phenotype is defined as the simultaneous presence of increased waist circumference (WC) and serum triglycerides (TG) levels and it has been associated with cardiometabolic risk in children and adolescents.

OBJECTIVE

: The objective was to evaluate the influence of HTW phenotype in the fasting glycemia and blood pressure in children and adolescents over one-year follow-up period.

METHODS

: It is a cohort study involving 492 children and adolescents from 7 to 15 years old, both genders, who were submitted to anthropometric, biochemical and clinical evaluation at the baseline, and also after 6 and 12 months of follow-up. Generalized Estimating Equation (GEE) models were calculated to evaluate the longitudinal influence of the HTW phenotype in the glycemia and blood pressure over one-year.

RESULTS

: It was observed a prevalence of 10.6% (n = 52) of HTW phenotype in the students. The GEE models identified that students with HTW phenotype had an increase of 3.87 mg/dl in the fasting glycemia mean (CI: 1.68-6.05) and of 3.67mmHg in the systolic blood pressure (SBP) mean (CI: 1.55-6.08) over one-year follow-up, after adjusting for confounding variables.

CONCLUSIONS

: The results of this study suggest that HTW phenotype is a risk factor for longitudinal changes in glycemia and SBP in children and adolescents over one-year follow-up period.

FUNDAMENTO

: O fenótipo de cintura hipertrigliceridêmica (CHT) é definido como a presença simultânea de circunferência de cintura (CC) e níveis séricos de triglicérides (TG) aumentados e tem sido associado com risco cardiometabólico em crianças e adolescentes.

OBJETIVO

: Avaliar a influência do fenótipo CHT na glicemia de jejum e na pressão arterial em crianças e adolescentes em um período de acompanhamento de um ano.

MÉTODOS:: Trata-se de um estudo de coorte envolvendo 492 crianças e adolescentes de 7 a 15 anos de ambos os sexos, que foram submetidos à avaliação antropométrica, bioquímica e clínica no início e também após 6 e 12 meses de seguimento. Os modelos de Equação de Estimulação Generalizada (GEE) foram calculados para avaliar a influência longitudinal do fenótipo CHT na glicemia e na pressão arterial ao longo de um ano.

RESULTADOS

: Foi observada uma prevalência de 10,6% (n = 52) do fenótipo CHT nos estudantes. Os modelos GEE identificaram que os estudantes com fenótipo CHT apresentaram aumento de 3,87 mg/dl na média de glicemia em jejum (IC: 1,68-6,05) e de 3,67 mmHg na pressão arterial sistólica media (PAS) (IC: 1,55-6,08) depois de um ano de acompanhamento, após ajuste para variáveis de confusão.

CONCLUSÕES:: Os resultados deste estudo sugerem que o fenótipo CHT é um fator de risco para alterações longitudinais da glicemia e da PAS em crianças e adolescentes em um período de um ano de seguimento.

摘要

背景

高甘油三酯血症腰围(HTW)表型被定义为腰围(WC)增加和血清甘油三酯(TG)水平同时存在,并且它与儿童和青少年的心血管代谢风险相关。

目的

目的是评估HTW表型在一年随访期内对儿童和青少年空腹血糖和血压的影响。

方法

这是一项队列研究,涉及492名7至15岁的儿童和青少年,男女均有,在基线时以及随访6个月和12个月后接受人体测量、生化和临床评估。计算广义估计方程(GEE)模型以评估HTW表型在一年中对血糖和血压的纵向影响。

结果

在学生中观察到HTW表型的患病率为10.6%(n = 52)。GEE模型确定,在调整混杂变量后,具有HTW表型的学生在一年随访期间空腹血糖平均值增加3.87mg/dl(CI:1.68 - 6.05),收缩压(SBP)平均值增加3.67mmHg(CI:1.55 - 6.08)。

结论

本研究结果表明,HTW表型是儿童和青少年在一年随访期内血糖和SBP纵向变化的危险因素。

基础

高甘油三酯血症腰围(CHT)表型被定义为腰围(CC)增加和血清甘油三酯(TG)水平同时存在,并且它与儿童和青少年的心血管代谢风险相关。

目的

评估CHT表型在一年随访期内对儿童和青少年空腹血糖和血压的影响。

方法

这是一项队列研究,涉及492名7至15岁的儿童和青少年,男女均有,在开始时以及随访6个月和12个月后接受人体测量、生化和临床评估。计算广义估计方程(GEE)模型以评估CHT表型在一年中对血糖和血压的纵向影响。

结果

在学生中观察到CHT表型的患病率为10.6%(n = 52)。GEE模型确定,在调整混杂变量后,具有CHT表型的学生在一年随访后空腹血糖平均值增加3.87mg/dl(CI:1.68 - 6.05),收缩压平均值增加3.67mmHg(IC:1.55 - 6.08)。

结论

本研究结果表明,CHT表型是儿童和青少年在一年随访期内血糖和PAS纵向变化的危险因素。

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