Guilherme Flávio Ricardo, Molena-Fernandes Carlos Alexandre, Hintze Luzia Jaeger, Fávero Maria Teresa Martins, Cuman Roberto Kenji Nakamura, Rinaldi Wilson
Department of Physical Education, State University of Maringa, Parana, Brazil.
Laboratory of Inflammation, Department of Pharmacy and Pharmacology, State University of Maringa, Maringa, Parana, Brazil.
PLoS One. 2014 Nov 14;9(11):e111724. doi: 10.1371/journal.pone.0111724. eCollection 2014.
To identify the prevalence of hypertriglyceridemic waist (HTW) phenotype and its association with metabolic abnormalities in schoolchildren.
A cross-sectional study, with a sample of 241 students aged 10 to 14 years from public schools (4 schools) and private (2 schools) from Paranavai town, in Parana State, Brazil. Anthropometric variables (weight, height, waist circumference) and levels of triglycerides, total cholesterol, HDL-C, non-HDL and LDL-C were analyzed. In statistical tests of Pearson partial correlation and multivariate logistic regression, considering p<0,05.
The prevalence of HTW was 20,7% among schoolchildren, 14,1% in males and 6,6% among females with higher proportions aged 10-12 years old. Multivariate analysis indicated that the students who attended private schools were nearly three times more likely (95% CI: 1,2-5,6), to be diagnosed with HTW compared with those who attended public schools (p = 0,006), and LDL-C was the only metabolic variable positively associated with the outcome (p = 0,001), where the students categorized with elevated serum levels had odds 4,2 times (95% CI: 1,6-10,9) having the HTW compared to students in appropriate levels.
This study showed higher prevalence of hypertriglyceridemic waist phenotype in students when compared to prospective studies in Brazil and worldwide. It also showed that the only metabolic alteration associated with HTW phenotype was LDL-C (low density lipoprotein).
确定学龄儿童中高甘油三酯血症腰围(HTW)表型的患病率及其与代谢异常的关联。
一项横断面研究,样本来自巴西巴拉那州帕拉纳瓦伊镇的公立学校(4所)和私立学校(2所)的241名10至14岁学生。分析人体测量变量(体重、身高、腰围)以及甘油三酯、总胆固醇、高密度脂蛋白胆固醇、非高密度脂蛋白和低密度脂蛋白胆固醇水平。在Pearson偏相关和多变量逻辑回归统计检验中,以p<0.05为标准。
学龄儿童中HTW的患病率为20.7%,男性为14.1%,女性为6.6%,10至12岁年龄段的比例更高。多变量分析表明,与就读公立学校的学生相比,就读私立学校的学生被诊断为HTW的可能性几乎高出三倍(95%置信区间:1.2 - 5.6)(p = 0.006),低密度脂蛋白胆固醇是与该结果呈正相关的唯一代谢变量(p = 0.001),血清水平升高的学生患HTW的几率是水平正常学生的4.2倍(95%置信区间:1.6 - 10.9)。
与巴西和全球的前瞻性研究相比,本研究显示学生中高甘油三酯血症腰围表型的患病率更高。研究还表明,与HTW表型相关的唯一代谢改变是低密度脂蛋白胆固醇。