深部组织中抗癌钌配合物的光活化：我们能深入到多深？
Photoactivation of Anticancer Ru Complexes in Deep Tissue: How Deep Can We Go?
作者信息
Sun Wen, Thiramanas Raweewan, Slep Leonardo D, Zeng Xiaolong, Mailänder Volker, Wu Si
机构信息
Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
Departamento de Química Inorgánica, AnalíticayQuímica Física, Facultad de Ciencias ExactasyNaturales, and, INQUIMAE Universidad de Buenos Aires/ CONICET, Pabellón 2, 3er piso, Ciudad Universitaria, C1428EHA, Ciudad Autónoma de Buenos Aires, Argentina.
出版信息
Chemistry. 2017 Aug 10;23(45):10832-10837. doi: 10.1002/chem.201701224. Epub 2017 Jul 19.
Activation of anticancer therapeutics such as ruthenium (Ru) complexes is currently a topic of intense investigation. The success of phototherapy relies on photoactivation of therapeutics after the light passes through skin and tissue. In this paper, the photoactivation of anticancer Ru complexes with 671-nm red light through tissue of different thicknesses was studied. Four photoactivatable Ru complexes with different absorption wavelengths were synthesized. Two of them (Ru3 and Ru4) were responsive to wavelengths in the "therapeutic window" (650-900 nm) and could be activated using 671-nm red light after passing through tissue up to 16-mm-thick. The other two (Ru1 and Ru2) could not be activated using red light. Additionally, activated Ru4 caused inhibition of cancer cells. These results suggest that photoactivatable Ru complexes are promising for applications in deep-tissue phototherapy.
诸如钌（Ru）配合物等抗癌疗法的激活目前是一个深入研究的课题。光疗的成功依赖于光穿过皮肤和组织后疗法的光激活。本文研究了用671纳米红光通过不同厚度组织对抗癌Ru配合物进行光激活的情况。合成了四种具有不同吸收波长的可光激活Ru配合物。其中两种（Ru3和Ru4）对“治疗窗口”（650 - 900纳米）中的波长有响应，在穿过厚度达16毫米的组织后可使用671纳米红光激活。另外两种（Ru1和Ru2）不能用红光激活。此外，激活后的Ru4会导致癌细胞受到抑制。这些结果表明，可光激活的Ru配合物在深部组织光疗应用中很有前景。
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