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转换酶抑制剂（卡托普利、依那普利、培哚普利）可预防麻醉大鼠梗死后期早期的心室颤动。

Converting enzyme inhibitors (captopril, enalapril, perindopril) prevent early-post infarction ventricular fibrillation in the anaesthetized rat.

作者信息

Ribuot C, Rochette L

机构信息

Laboratoire de Pharmacodynamie et de Physiologie Pharmaceutique, Faculté de Pharmacie-Université de Dijon, France.

出版信息

Cardiovasc Drugs Ther. 1987;1(1):51-5. doi: 10.1007/BF02125833.

DOI:10.1007/BF02125833
PMID:2856461
Abstract

The angiotensin-converting enzyme inhibitors, captopril, enalapril and perindopril, exert antiarrhythmic effects on early post-infarction arrhythmias in anaesthetized rats. These studies support the hypothesis that converting enzyme inhibitors could have a "cardioprotective" effect, but the doses used are probably "high" in relation to those therapeutically applicable to man.

摘要

血管紧张素转换酶抑制剂卡托普利、依那普利和培哚普利，对麻醉大鼠心肌梗死后早期心律失常具有抗心律失常作用。这些研究支持了转换酶抑制剂可能具有“心脏保护”作用的假说，但所用剂量相对于适用于人类治疗的剂量而言可能“过高”。

相似文献

1
Converting enzyme inhibitors (captopril, enalapril, perindopril) prevent early-post infarction ventricular fibrillation in the anaesthetized rat.转换酶抑制剂（卡托普利、依那普利、培哚普利）可预防麻醉大鼠梗死后期早期的心室颤动。
Cardiovasc Drugs Ther. 1987;1(1):51-5. doi: 10.1007/BF02125833.
2
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3
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引用本文的文献

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Effect of captopril on membrane currents of ventricular myocytes.
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2
Effect of the angiotensin-converting enzyme inhibitor, perindoprilat, and of angiotensin-II on the transient inward current of rabbit ventricular myocytes.
Cardiovasc Drugs Ther. 1994 Aug;8(4):647-51. doi: 10.1007/BF00877418.
3
Perindopril. A review of its pharmacokinetics and clinical pharmacology.培哚普利。其药代动力学与临床药理学综述。
Drugs. 1990;39 Suppl 1:49-63. doi: 10.2165/00003495-199000391-00009.
4

本文引用的文献

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Simple techniques for the surgical occlusion of coronary vessels in the rat.大鼠冠状动脉血管手术闭塞的简单技术。
Angiology. 1960 Oct;11:398-407. doi: 10.1177/000331976001100505.
2
Coronary artery ligation in anesthetized rats as a method for the production of experimental dysrhythmias and for the determination of infarct size.在麻醉大鼠中进行冠状动脉结扎，作为产生实验性心律失常和测定梗死面积的一种方法。
J Pharmacol Methods. 1980 Jun;3(4):357-68. doi: 10.1016/0160-5402(80)90077-7.
3
Calcium antagonists prevent early post-infarction ventricular fibrillation.
Lack of effect of perindoprilat, an angiotensin-I converting enzyme inhibitor, during coronary artery occlusion and reperfusion in the anesthetized dog.血管紧张素转换酶抑制剂培哚普利拉在麻醉犬冠状动脉闭塞及再灌注过程中无作用。
Cardiovasc Drugs Ther. 1991 Dec;5(6):1047-8. doi: 10.1007/BF00143535.
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Perindopril. A review of its pharmacological properties and therapeutic use in cardiovascular disorders.培哚普利。对其药理特性及在心血管疾病治疗中的应用综述。
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钙拮抗剂可预防心肌梗死后早期心室颤动。
Eur J Pharmacol. 1981 Nov 5;75(4):179-85. doi: 10.1016/0014-2999(81)90543-4.
4
Captopril reduces purine loss and reperfusion arrhythmias in the rat heart after coronary artery occlusion.卡托普利可减少大鼠冠状动脉闭塞后心脏的嘌呤损失和再灌注心律失常。
Eur J Pharmacol. 1984 Apr 13;100(1):113-7. doi: 10.1016/0014-2999(84)90323-6.
5
The converting enzyme inhibitor captopril stimulates prostacyclin synthesis by isolated rat aorta.转换酶抑制剂卡托普利可刺激离体大鼠主动脉合成前列环素。
Eur J Pharmacol. 1983 Aug 5;91(4):501-4. doi: 10.1016/0014-2999(83)90176-0.
6
Prostaglandins and the cardiovascular system.前列腺素与心血管系统。
Br Heart J. 1983 May;49(5):405-9. doi: 10.1136/hrt.49.5.405.
7
Limitation of experimental infarct size by an angiotensin-converting enzyme inhibitor.血管紧张素转换酶抑制剂对实验性梗死面积的限制作用。
Circulation. 1982 Jan;65(1):40-8. doi: 10.1161/01.cir.65.1.40.
8
Is tissue converting enzyme inhibition a determinant of the antihypertensive efficacy of converting enzyme inhibitors? Studies with the two different compounds, Hoe498 and MK421, in spontaneously hypertensive rats.组织转换酶抑制作用是转换酶抑制剂降压疗效的决定因素吗？在自发性高血压大鼠中对两种不同化合物Hoe498和MK421的研究。
J Cardiovasc Pharmacol. 1984 Sep-Oct;6(5):872-80. doi: 10.1097/00005344-198409000-00021.
9
Cardioprotective effects of enalapril in acute myocardial ischemia.依那普利对急性心肌缺血的心脏保护作用。
Pharmacology. 1984;29(2):61-9. doi: 10.1159/000137993.
10
Haemodynamic responses to specific renin-angiotensin inhibitors in hypertension and congestive heart failure. A review.高血压和充血性心力衰竭患者对特定肾素-血管紧张素抑制剂的血流动力学反应。综述。
Drugs. 1984 Aug;28(2):144-69. doi: 10.2165/00003495-198428020-00004.