转换酶抑制剂（卡托普利、依那普利、培哚普利）可预防麻醉大鼠梗死后期早期的心室颤动。
Converting enzyme inhibitors (captopril, enalapril, perindopril) prevent early-post infarction ventricular fibrillation in the anaesthetized rat.
作者信息
Ribuot C, Rochette L
机构信息
Laboratoire de Pharmacodynamie et de Physiologie Pharmaceutique, Faculté de Pharmacie-Université de Dijon, France.
出版信息
Cardiovasc Drugs Ther. 1987;1(1):51-5. doi: 10.1007/BF02125833.
PMID:2856461
Abstract
The angiotensin-converting enzyme inhibitors, captopril, enalapril and perindopril, exert antiarrhythmic effects on early post-infarction arrhythmias in anaesthetized rats. These studies support the hypothesis that converting enzyme inhibitors could have a "cardioprotective" effect, but the doses used are probably "high" in relation to those therapeutically applicable to man.
摘要
血管紧张素转换酶抑制剂卡托普利、依那普利和培哚普利，对麻醉大鼠心肌梗死后早期心律失常具有抗心律失常作用。这些研究支持了转换酶抑制剂可能具有“心脏保护”作用的假说，但所用剂量相对于适用于人类治疗的剂量而言可能“过高”。
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