Düsing R, Scherhag R, Landsberg G, Glänzer K, Kramer H J
Eur J Pharmacol. 1983 Aug 5;91(4):501-4. doi: 10.1016/0014-2999(83)90176-0.
In the present study, pretreatment of rats with captopril significantly stimulated prostacyclin (PGI2) synthesis by their isolated aorta. This effect was maximal at captopril doses of 1.0 mumol/kg body weight. When added directly into the incubation buffer, captopril at final concentrations of 50 and 500 nM also increased the synthesis of PGI2 by isolated rat aorta. Our results show that captopril stimulates PGI2 synthesis in vascular tissue and that this effect may be due at least in part to a direct action of this substance.
在本研究中，用卡托普利对大鼠进行预处理可显著刺激其离体主动脉合成前列环素（PGI2）。在卡托普利剂量为1.0 μmol/kg体重时，这种作用达到最大。当直接添加到孵育缓冲液中时，终浓度为50和500 nM的卡托普利也可增加离体大鼠主动脉的PGI2合成。我们的结果表明，卡托普利可刺激血管组织中PGI2的合成，且这种作用可能至少部分归因于该物质的直接作用。
