Kim Soomin, Jang Ji Eun, Kim Jihee, Lee Young In, Lee Dong Won, Song Seung Yong, Lee Ju Hee
Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, South Korea.
Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Food Chem Toxicol. 2017 Aug;106(Pt A):367-375. doi: 10.1016/j.fct.2017.05.060. Epub 2017 May 28.
Natural plant oils have been used as a translational alternative to modern medicine. Particularly, virgin coconut oil (VCO) has gained popularity because of its potential benefits in pharmaceutical, nutritional, and cosmetic applications. Cultured coconut extract (CCE) is an alternative end product of VCO, which undergoes a further bacterial fermentation process. This study aimed to investigate the effects of CCE on human skin. We analyzed the expression of skin barrier molecules and collagens after applying CCE on human explanted skin. To evaluate the anti-inflammatory properties of CCE, the expression of inflammatory markers was analyzed after ultraviolet B (UVB) irradiation. The CCE-treated group showed increased expression of cornified cell envelope components, which contribute to protective barrier functions of the stratum corneum. Further, the expression of inflammatory markers was lower in the CCE-treated group after exposure to UVB radiation. These results suggest an anti-inflammatory effect of CCE against UVB irradiation-induced inflammation. Additionally, the CCE-treated group showed increased collagen and hyaluronan synthase-3 expression. In our study, CCE showed a barrier-enhancing effect and anti-inflammatory properties against ex vivo UVB irradiation-induced inflammation. The promising effect of CCE may be attributed to its high levels of polyphenols and fatty acid components.
天然植物油已被用作现代医学的一种转化替代物。特别是初榨椰子油（VCO），因其在制药、营养和化妆品应用中的潜在益处而受到欢迎。培养椰子提取物（CCE）是VCO的一种替代终产物，它经过进一步的细菌发酵过程。本研究旨在调查CCE对人体皮肤的影响。我们在将CCE应用于人体离体皮肤后，分析了皮肤屏障分子和胶原蛋白的表达。为了评估CCE的抗炎特性，在紫外线B（UVB）照射后分析了炎症标志物的表达。CCE处理组显示角质化细胞包膜成分的表达增加，这有助于角质层的保护屏障功能。此外，在暴露于UVB辐射后，CCE处理组中炎症标志物的表达较低。这些结果表明CCE对UVB照射诱导的炎症具有抗炎作用。此外，CCE处理组显示胶原蛋白和透明质酸合酶-3的表达增加。在我们的研究中，CCE对离体UVB照射诱导的炎症显示出屏障增强作用和抗炎特性。CCE的这种有前景的作用可能归因于其高水平的多酚和脂肪酸成分。
