Noma Hidetaka, Mimura Tatsuya, Yasuda Kanako, Motohashi Ryosuke, Kotake Osamu, Shimura Masahiko
Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan.
Ophthalmologica. 2017;238(1-2):81-88. doi: 10.1159/000475603. Epub 2017 Jun 1.
Aqueous levels of soluble vascular endothelial growth factor receptor (sVEGFR) and inflammatory factors were measured in 35 patients (37 eyes) with diabetic macular edema (DME) receiving anti-vascular endothelial growth factor (VEGF) therapy. Aqueous levels of growth factors (VEGF, placental growth factor [PlGF], and platelet-derived growth factor AA [PDGF-AA]), sVEGFR-1 and -2, soluble intercellular adhesion molecule 1, monocyte chemotactic protein (MCP)-1, interleukin (IL)-6, -8, -12, and -13, and interferon-inducible 10-kDa protein (IP-10) were significantly higher in the DME group than in the nondiabetic control group. The sVEGFR-2 level was significantly correlated with the neurosensory retinal thickness, as well as with the levels of growth factors (VEGF and PDGF-AA) and inflammatory factors (MCP-1, IL-6, and IL-8). Three growth factors (VEGF, PlGF, and PDGF-AA) were also significantly correlated with each other, as were sVEGFR-1 or -2 and the inflammatory factors (MCP-1, IL-6, IL-8, and IP-10). These findings suggest that sVEGFRs and growth/inflammatory factors have an important role in DME.
对35例（37只眼）接受抗血管内皮生长因子（VEGF）治疗的糖尿病性黄斑水肿（DME）患者测量房水中可溶性血管内皮生长因子受体（sVEGFR）和炎症因子水平。DME组房水中生长因子（VEGF、胎盘生长因子[PlGF]和血小板衍生生长因子AA[PDGF-AA]）、sVEGFR-1和-2、可溶性细胞间黏附分子1、单核细胞趋化蛋白（MCP）-1、白细胞介素（IL）-6、-8、-12和-13以及干扰素诱导的10 kDa蛋白（IP-10）水平显著高于非糖尿病对照组。sVEGFR-2水平与神经感觉视网膜厚度以及生长因子（VEGF和PDGF-AA）和炎症因子（MCP-1、IL-6和IL-8）水平显著相关。三种生长因子（VEGF、PlGF和PDGF-AA）之间也显著相关，sVEGFR-1或-2与炎症因子（MCP-1、IL-6、IL-8和IP-10）之间也显著相关。这些发现表明sVEGFRs和生长/炎症因子在DME中起重要作用。
