Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod, RussiabFederal Scientific Research Centre "Crystallography and Photonics" of the Russian Academy of Sciences, Institute of Photonic Technologies, Moscow, Russia.
Federal Scientific Research Centre "Crystallography and Photonics" of the Russian Academy of Sciences, Institute of Photonic Technologies, Moscow, Russia.
J Biomed Opt. 2017 Sep 1;22(9):91515. doi: 10.1117/1.JBO.22.9.091515.
Pores are vital for functioning of avascular tissues. Laser-induced pores play an important role in the process of cartilage regeneration. The aim of any treatment for osteoarthritis is to repair hyaline-type cartilage. The aims of this study are to answer two questions: (1) How do laser-assisted pores affect the cartilaginous cells to synthesize hyaline cartilage (HC)? and (2) How can the size distribution of pores arising in the course of laser radiation be controlled? We have shown that in cartilage, the pores arise predominately near chondrocytes, which promote nutrition of cells and signal molecular transfer that activates regeneration of cartilage. In vivo laser treatment of damaged cartilage of miniature pig joints provides cellular transformation and formation of HC. We propose a simple model of pore formation in biopolymers that paves the way for going beyond the trial-and-error approach when choosing an optimal laser treatment regime. Our findings support the approach toward laser healing of osteoarthritis.
孔对于无血管组织的功能至关重要。激光诱导的孔在软骨再生过程中起着重要作用。任何骨关节炎治疗的目的都是修复透明软骨。本研究的目的是回答两个问题：(1)激光辅助孔如何影响软骨细胞合成透明软骨（HC）？(2)如何控制激光辐射过程中产生的孔的大小分布？我们已经表明，在软骨中，孔主要出现在软骨细胞附近，这促进了细胞的营养和信号分子的传递，从而激活了软骨的再生。体内激光治疗小型猪关节损伤软骨可提供细胞转化和形成 HC。我们提出了一种生物聚合物中孔形成的简单模型，为在选择最佳激光治疗方案时超越试错方法铺平了道路。我们的研究结果支持激光治疗骨关节炎的方法。
