Departamento de Medicina y Cirugía Animal, Facultad de Veterinaria, Universidad de Córdoba, Hospital Clínico Veterinario, Campus de Rabanales, Ctra. Madrid-Cádiz Km 396, 14014 Córdoba, Spain.
Fundación García-Cugat, Plaza Alfonso Comín 5-7, 08023 Barcelona, Spain.
Int J Mol Sci. 2021 Dec 11;22(24):13329. doi: 10.3390/ijms222413329.
Several collagen subtypes have been identified in hyaline articular cartilage. The main and most abundant collagens are type II, IX and XI collagens. The minor and less abundant collagens are type III, IV, V, VI, X, XII, XIV, XVI, XXII, and XXVII collagens. All these collagens have been found to play a key role in healthy cartilage, regardless of whether they are more or less abundant. Additionally, an exhaustive evaluation of collagen fibrils in a repaired cartilage tissue after a chondral lesion is necessary to determine the quality of the repaired tissue and even whether or not this repaired tissue is considered hyaline cartilage. Therefore, this review aims to describe in depth all the collagen types found in the normal articular cartilage structure, and based on this, establish the parameters that allow one to consider a repaired cartilage tissue as a hyaline cartilage.
几种胶原亚型已在透明软骨中被鉴定。主要且最丰富的胶原是 II 型、IX 型和 XI 型胶原。次要且较少的胶原是 III 型、IV 型、V 型、VI 型、X 型、XII 型、XIV 型、XVI 型、XXII 型和 XXVII 型胶原。所有这些胶原都被发现对健康软骨起着关键作用，无论它们是更丰富还是较少。此外，对软骨损伤后修复的软骨组织中的胶原纤维进行详尽的评估是必要的，以确定修复组织的质量，甚至确定这种修复组织是否被认为是透明软骨。因此，本综述旨在深入描述在正常关节软骨结构中发现的所有胶原类型，并在此基础上，建立允许人们将修复的软骨组织视为透明软骨的参数。
