Qiao Peng-Fei, Shi Feng, Jiang Ming-Fang, Gao Yang, Niu Guang-Ming
Department of Magnetic Resonance Imaging, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010050, P.R. China.
Department of Radiology, Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine, Hohhot, Inner Mongolia Autonomous Region 010050, P.R. China.
Exp Ther Med. 2017 May;13(5):1665-1670. doi: 10.3892/etm.2016.3551. Epub 2016 Jul 26.
The present study aimed to observe the structural changes of the extracorticospinal tract in Parkinson's disease (PD) using susceptibility-weighted imaging (SWI) and diffusion tensor imaging (DTI) magnetic resonance (MR) scans. The association of DTI parameters and brain-iron accumulation with PD was examined and imaging signs useful in the diagnosis of PD were explored. The study included 30 patients with PD and 30 age- and gender-matched healthy controls who underwent routine MR, SWI and DTI scans. The corrected phase (CP) values of the substantia nigra (SN), red nucleus (RN), globus pallidus (GP) and putamen (PUT) were measured, and fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values were obtained. Significant differences were found in the CP values between the PD and control groups in the SN, RN and PUT, but there were no differences in other regions of interest (ROIs). The FA values of the SN and PUT in the PD group were significantly decreased compared with those of the control group, but there was no significant difference in the FA values of the GP. Furthermore, there was no significant inter-group difference in the ADC values of any ROIs. In conclusion, SWI is a method useful for evaluating brain-iron deposition in PD. Increasing iron storage levels have previously been shown to be associated with PD pathogenesis but not with the degree of PD severity. FA values may be useful for diagnosing PD, and DTI may offer some insight into PD pathomechanisms and clinical diagnosis.
本研究旨在利用磁共振成像（MRI）中的磁敏感加权成像（SWI）和扩散张量成像（DTI）观察帕金森病（PD）患者皮质脊髓外束的结构变化。研究了DTI参数和脑铁沉积与PD的相关性，并探索了对PD诊断有用的影像学征象。该研究纳入了30例PD患者和30例年龄及性别匹配的健康对照者，所有受试者均接受了常规MRI、SWI和DTI扫描。测量了黑质（SN）、红核（RN）、苍白球（GP）和壳核（PUT）的校正相位（CP）值，并获得了分数各向异性（FA）和表观扩散系数（ADC）值。PD组和对照组在SN、RN及PUT的CP值上存在显著差异，但在其他感兴趣区域（ROI）无差异。PD组SN和PUT的FA值与对照组相比显著降低，但GP的FA值无显著差异。此外，各ROI的ADC值在组间无显著差异。总之，SWI是评估PD脑铁沉积的一种有用方法。先前研究表明，铁储存水平升高与PD发病机制有关，但与PD严重程度无关。FA值可能有助于PD的诊断，DTI可能为PD的发病机制和临床诊断提供一些见解。
