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中药注射剂快速过敏皮肤试验检测仪的设计与实现

Design and implementation of fast allergy skin test detector for traditional Chinese medicine injections.

作者信息

Xiao Ying, Zhao Yubin, Xie Yanming

机构信息

Department of Bioengineering, School of Chemical Engineering, Shijiazhuang University, Shijiazhuang, Hebei 050035, P.R. China.

Medical and Electronic Experimental Center, The TCM Hospital of Shijiazhuang Affiliated to Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China.

出版信息

Exp Ther Med. 2017 May;13(5):1884-1890. doi: 10.3892/etm.2017.4221. Epub 2017 Mar 10.

DOI:10.3892/etm.2017.4221
PMID:28565781
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5443211/
Abstract

Traditional Chinese medicine (TCM) injections are prepared from active substances extracted from TCMs and other natural medicines to establish scientific and technological methods, based on TCM hypotheses and experiences. A device was designed to provide a fast allergy skin test detector for TCM injections that could be applied to drugs of a single component or complex components. A novel fast allergy skin test detector for TCM injections was developed combining direct-current main, drug solution permeation devices of various shape that were compatible with the skin test electrode, nano-sponge patch adsorption, and flexible liposome coverage technologies with high-amplitude pulse. The detector was characterized by simple structure, easy manipulation, low dose of drug required for the skin test, no irritation to human skin, and low-false positive rate. According to the pilot clinical use, it was able to meet the clinical demand and was promising for the prevention of allergy to TCM injections.

摘要

中药注射剂是从中药和其他天然药物中提取的活性物质制备而成，基于中医理论和经验建立科学技术方法。设计了一种装置，用于提供一种快速的中药注射剂过敏皮肤测试检测器，该检测器可应用于单一组分或复杂组分的药物。结合直流主电路、与皮肤测试电极兼容的各种形状的药物溶液渗透装置、纳米海绵贴片吸附和具有高振幅脉冲的柔性脂质体包被技术，开发了一种新型的快速中药注射剂过敏皮肤测试检测器。该检测器具有结构简单、操作方便、皮肤测试所需药物剂量低、对人体皮肤无刺激、假阳性率低等特点。根据初步临床应用，它能够满足临床需求，对预防中药注射剂过敏具有广阔前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c88/5443211/f5dfe38466b8/etm-13-05-1884-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c88/5443211/6ab98327160f/etm-13-05-1884-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c88/5443211/1de99483e4c1/etm-13-05-1884-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c88/5443211/1b745f7b9927/etm-13-05-1884-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c88/5443211/b1b07a9dbbf9/etm-13-05-1884-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c88/5443211/76a426e0c844/etm-13-05-1884-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c88/5443211/f7d22a226373/etm-13-05-1884-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c88/5443211/c4a71d90b852/etm-13-05-1884-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c88/5443211/f5dfe38466b8/etm-13-05-1884-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c88/5443211/6ab98327160f/etm-13-05-1884-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c88/5443211/1de99483e4c1/etm-13-05-1884-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c88/5443211/1b745f7b9927/etm-13-05-1884-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c88/5443211/b1b07a9dbbf9/etm-13-05-1884-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c88/5443211/76a426e0c844/etm-13-05-1884-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c88/5443211/f7d22a226373/etm-13-05-1884-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c88/5443211/c4a71d90b852/etm-13-05-1884-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c88/5443211/f5dfe38466b8/etm-13-05-1884-g07.jpg

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本文引用的文献

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Detecting drug-herbal interaction using a spontaneous reporting system database: an example with benzylpenicillin and qingkailing injection.使用自发报告系统数据库检测药物-草药相互作用：以苄青霉素和清开灵注射液为例。
Eur J Clin Pharmacol. 2015 Sep;71(9):1139-45. doi: 10.1007/s00228-015-1898-8. Epub 2015 Jul 11.
2
[Establishment of model of traditional Chinese medicine injections post-marketing safety monitoring].[中药注射剂上市后安全性监测模型的建立]
Zhongguo Zhong Yao Za Zhi. 2013 Sep;38(18):2974-8.
3
Effects of Shenfu injection and its main components on the contraction of isolated rat thoracic aortic rings.
参附注射液及其主要成分对大鼠离体胸主动脉环收缩的影响。
PLoS One. 2013 Oct 30;8(10):e78026. doi: 10.1371/journal.pone.0078026. eCollection 2013.
4
[Discussion on establishment of quality control system for intensive hospital monitoring on traditional Chinese medicine injections].[关于建立中药注射剂医院集中监测质量控制体系的探讨]
Zhongguo Zhong Yao Za Zhi. 2012 Sep;37(18):2689-91.
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Zhongguo Zhong Yao Za Zhi. 2011 Jul;36(14):1905-9.
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[Efficacy of shenfu injection as adjuvant therapy in treating patients of ischemic cardiomyopathy with heart insufficiency].参附注射液辅助治疗缺血性心肌病合并心力衰竭患者的疗效
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[Safety evaluation of traditional Chinese medicine injections and study of related key technology].中药注射剂安全性评价及相关关键技术研究
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[Necessity of applying pharmacovigilance in post-marketing safety monitoring of traditional Chinese medicine injections].[中药注射剂上市后安全性监测中应用药物警戒的必要性]
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