Shi Shuaitao, Wang Guoquan, Zhang Kewei, Zhang Zhidong, Liang Kai, Li Kun, Li Weixiao, Zhai Shuiting
Interventional Therapy Center, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, P.R. China.
Exp Ther Med. 2017 May;13(5):1917-1921. doi: 10.3892/etm.2017.4207. Epub 2017 Mar 9.
We investigated the expression levels and clinical significance of S100β protein in patients with vascular dementia (VD) after basal ganglia hemorrhage. From June 2014 to December 2015, in 138 patients with basal ganglia hemorrhage, we carried out the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) in patients on the day before the operation, the day after the operation and 9 days after the operation. Thirty-two patients (blood vessel group) had cognitive dysfunction and 106 patients (control group) had VD. One hundred thirty-eight cases of healthy adult volunteers were treated in Henan Provincial People's Hospital and were selected in the same period as healthy controls. The expression levels of serum S100β in the three groups were tested through the ELISA method and the statistical analysis was carried out. In VD patients, the serum S100β levels of patients were significantly higher than VD and healthy control groups; differences were statistically significant (P<0.05). However, there was no significant difference between those without VD after operation and the healthy control group (P>0.05). The correlation analysis was carried out with serum S100β as an independent variable and mean arterial pressure, BMI, MMSE and MoCA scores as dependent variables. Our results suggest that S100β expression levels were negatively correlated to the MMSE score (rs=-4.19) and the difference was statistically significant (P<0.05). The length of hospital stay of patients with basal ganglia hemorrhage associated with VD was significantly extended, with a mean of 23.4±2.8 days. The expression levels of S100β protein in the serum of patients with VD after basal ganglia hemorrhage was significantly increased and negatively correlated to the cognitive function of patients. Therefore, it can be used as a differential diagnosis indicator of VD after the basal ganglia hemorrhage and treatment target point of the VD.
我们研究了基底节区出血后血管性痴呆（VD）患者中S100β蛋白的表达水平及其临床意义。2014年6月至2015年12月，对138例基底节区出血患者在术前、术后第1天和术后第9天进行简易精神状态检查表（MMSE）和蒙特利尔认知评估量表（MoCA）检查。32例（血管组）有认知功能障碍，106例（对照组）有VD。选取同期在河南省人民医院接受治疗的138例健康成年志愿者作为健康对照。采用酶联免疫吸附测定（ELISA）法检测三组血清S100β的表达水平并进行统计学分析。在VD患者中，其血清S100β水平显著高于非VD患者和健康对照组；差异具有统计学意义（P<0.05）。然而，术后无VD患者与健康对照组之间无显著差异（P>0.05）。以血清S100β为自变量，平均动脉压、体重指数、MMSE和MoCA评分作为因变量进行相关性分析。我们的结果表明，S100β表达水平与MMSE评分呈负相关（rs=-4.19），差异具有统计学意义（P<0.05）。基底节区出血合并VD患者的住院时间显著延长，平均为23.4±2.8天。基底节区出血后VD患者血清中S100β蛋白表达水平显著升高，且与患者认知功能呈负相关。因此，其可作为基底节区出血后VD的鉴别诊断指标及VD的治疗靶点。
