Altern Ther Health Med. 2024 Apr;30(4):54-59.
To observe the levels of serum 3-nitrotyrosine (3-NT), neuronal PAS domain protein 4 (NPASDP-4), and S100β protein in patients diagnosed with cerebral infarction and analyze their correlation with cognitive dysfunction in these patients.
The study included a cohort of 158 patients suffering from cerebral infarction who were admitted to the Liwan District Hospital of Traditional Chinese Medicine between January 2021 and December 2022. After stabilizing vital signs, all patients underwent the Montreal Cognitive Assessment (MoCA) to assess their cognitive function. Based on the assessment results, they were divided into two groups: the cognitive dysfunction group (121 cases) and the normal cognitive function group (37 cases). The baseline characteristics and serum levels of 3-NT, neuronal PAS domain protein 4 (NPASDP-4), and S100β protein were compared in the patient cohorts. Furthermore, the correlation between these three indicators and cognitive function in patients suffering from cerebral infarction was analyzed. A logistic regression model was constructed to analyze how serum levels of 3-NT, NPASDP-4, and S100β protein levels affected cognitive function in patients suffering from cerebral infarction. ROC curve analysis was conducted to assess the predictive value of serum 3-NT, NPASDP-4, and S100β protein levels for cognitive function in patients suffering from cerebral infarction.
Among the 158 patients with cerebral infarction, 121 (76.58%) had cognitive dysfunction, while 37 (23.42%) had normal cognitive function. The levels of 3-NT, NPASDP-4, and S100β protein were found to be significantly higher in the cognitive dysfunction group compared to the normal cognitive function group (t = 5.788, 7.774, 6.460; P = .000, .000, .000). The point-biserial correlation analysis results showed a positive correlation between serum levels of 3-NT, NPASDP-4, and S100β protein and the occurrence of cognitive dysfunction in patients suffering from cerebral infarction (r=0.420, 0.529, 0.424; P = .000, .000, .000). The logistic regression model demonstrated that serum levels of 3-NT(95%CI: 1.299-2.603), NPASDP-4(95%CI: 1.487-3.386), and S100β protein(95%CI: 1.153-8.746) were risk factors for cognitive dysfunction in patients suffering from cerebral infarction (OR=1.839, 2.244, 1.429; P = .001, .000, .240). ROC curve analysis demonstrated that serum 3-NT, NPASDP-4, and S100β protein levels exhibited a certain predictive value for cognitive function in patients with cerebral infarction (AUC = 0.789, 0.881, 0.820).
Serum levels of 3-NT, NPASDP-4, and S100β protein are closely related to the cognitive function of patients with cerebral infarction, and abnormal changes in these levels may exacerbate cognitive dysfunction in these patients.
观察诊断为脑梗死患者血清 3-硝基酪氨酸（3-NT）、神经元 PAS 结构域蛋白 4（NPASDP-4）和 S100β 蛋白水平，并分析其与患者认知功能障碍的相关性。
该研究纳入了 2021 年 1 月至 2022 年 12 月期间在荔湾区中医院就诊的 158 例脑梗死患者。在生命体征稳定后，所有患者均接受蒙特利尔认知评估（MoCA）以评估其认知功能。根据评估结果，将他们分为认知功能障碍组（121 例）和正常认知功能组（37 例）。比较患者队列的基线特征和血清 3-NT、NPASDP-4 和 S100β 蛋白水平。此外，还分析了这三个指标与脑梗死患者认知功能的相关性。构建了一个逻辑回归模型，分析血清 3-NT、NPASDP-4 和 S100β 蛋白水平如何影响脑梗死患者的认知功能。采用 ROC 曲线分析评估血清 3-NT、NPASDP-4 和 S100β 蛋白水平对脑梗死患者认知功能的预测价值。
在 158 例脑梗死患者中，121 例（76.58%）存在认知功能障碍，37 例（23.42%）认知功能正常。与正常认知功能组相比，认知功能障碍组患者的血清 3-NT、NPASDP-4 和 S100β 蛋白水平显著升高（t=5.788、7.774、6.460；P=0.000、0.000、0.000）。点双列相关分析结果显示，血清 3-NT、NPASDP-4 和 S100β 蛋白水平与脑梗死患者认知功能障碍的发生呈正相关（r=0.420、0.529、0.424；P=0.000、0.000、0.000）。逻辑回归模型表明，血清 3-NT（95%CI：1.299-2.603）、NPASDP-4（95%CI：1.487-3.386）和 S100β 蛋白（95%CI：1.153-8.746）是脑梗死患者认知功能障碍的危险因素（OR=1.839、2.244、1.429；P=0.001、0.000、0.240）。ROC 曲线分析表明，血清 3-NT、NPASDP-4 和 S100β 蛋白水平对脑梗死患者的认知功能具有一定的预测价值（AUC=0.789、0.881、0.820）。
血清 3-NT、NPASDP-4 和 S100β 蛋白水平与脑梗死患者的认知功能密切相关，这些水平的异常变化可能会加重患者的认知功能障碍。
