Nakano Fumihito, Sakushima Ken, Umeki Reona, Yabe Ichiro, Endoh Akira, Sasaki Hidenao
Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan; Department of Neurology, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan.
Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan; Department of Pharmaceutical and Medical Device Regulatory Science, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
J Neurol Sci. 2017 Jul 15;378:45-48. doi: 10.1016/j.jns.2017.04.033. Epub 2017 Apr 20.
Despite recent studies examining the association between neurodegenerative diseases and mitochondrial dysfunction, there are not sufficient data on factors that influence cerebrospinal fluid (CSF) lactate levels. Thus, we investigated factors that affect CSF lactate levels in neurodegenerative diseases. We extracted laboratory findings, including CSF lactate, glucose, and protein levels, and demographic and background information, including age and gender, from the electronic medical records of patients with neurodegenerative diseases in order to explore factors that have an impact CSF lactate levels. These patients had been admitted to our department and underwent a CSF examination between April 2007 and March 2015. Data from 83 patients (average age 64.5years; 45 males and 38 females) were analyzed. The patients' diagnoses included amyotrophic lateral sclerosis, multiple system atrophy, spinocerebellar degeneration, corticobasal syndrome, Parkinson's disease, and Huntington's disease. CSF lactate levels were higher in patients with a neurodegenerative disease who were aged 65years and older relative to those who were aged under 65years (p<0.05), and CSF lactate and glucose levels showed a moderate positive correlation (r=0.487). Age and CSF glucose levels influenced CSF lactate levels even after adjusting for gender, age, CSF protein levels, and CSF glucose levels. When investigating CSF lactate levels in neurodegenerative diseases, it is necessary to consider patients' age and CSF glucose levels.
尽管最近有研究探讨神经退行性疾病与线粒体功能障碍之间的关联，但关于影响脑脊液（CSF）乳酸水平的因素的数据仍不充分。因此，我们调查了神经退行性疾病中影响脑脊液乳酸水平的因素。我们从神经退行性疾病患者的电子病历中提取了包括脑脊液乳酸、葡萄糖和蛋白质水平在内的实验室检查结果，以及包括年龄和性别在内的人口统计学和背景信息，以探索影响脑脊液乳酸水平的因素。这些患者于2007年4月至2015年3月期间入住我科并接受了脑脊液检查。对83例患者（平均年龄64.5岁；男性45例，女性38例）的数据进行了分析。患者的诊断包括肌萎缩侧索硬化症、多系统萎缩、脊髓小脑变性、皮质基底节综合征、帕金森病和亨廷顿病。65岁及以上的神经退行性疾病患者的脑脊液乳酸水平高于65岁以下的患者（p<0.05），脑脊液乳酸水平与葡萄糖水平呈中度正相关（r=0.487）。即使在对性别、年龄、脑脊液蛋白质水平和脑脊液葡萄糖水平进行校正后，年龄和脑脊液葡萄糖水平仍会影响脑脊液乳酸水平。在研究神经退行性疾病中的脑脊液乳酸水平时，有必要考虑患者的年龄和脑脊液葡萄糖水平。
