Tan Qing Che, Xing Xiao Wei, Zhang Jia Tang, He Mian Wang, Ma Yu Bao, Wu Lei, Wang Xiaolin, Wang Hong Fen, Yu Sheng Yuan
Medical School of Chinese PLA, Beijing, China.
Hainan Branch of People's Liberation Army General Hospital, Sanya, China.
Front Neurol. 2023 Apr 27;14:1103026. doi: 10.3389/fneur.2023.1103026. eCollection 2023.
We aimed to determine a method to identify normal cerebrospinal fluid (CSF) glucose levels by examining the correlation between blood and CSF glucose levels in patients with normal and abnormal glucose metabolism.
One hundred ninety-five patients were divided into two groups according to their glucose metabolism. The glucose levels were obtained from CSF and fingertip blood at 6, 5, 4, 3, 2, 1, and 0 h before lumbar puncture. SPSS 22.0 software was used for the statistical analysis.
In both the normal and abnormal glucose metabolism groups, CSF glucose levels increased with blood glucose levels at 6, 5, 4, 3, 2, 1, and 0 h before lumbar puncture. In the normal glucose metabolism group, the CSF/blood glucose ratio range was 0.35-0.95 at 0-6 h before lumbar puncture, and the CSF/average blood glucose ratio range was 0.43-0.74. In the abnormal glucose metabolism group, the CSF/blood glucose ratio range was 0.25-1.2 at 0-6 h before lumbar puncture, and the CSF/average blood glucose ratio range was 0.33-0.78.
The CSF glucose level is influenced by the blood glucose level 6 h before lumbar puncture. In patients with normal glucose metabolism, direct measurement of the CSF glucose level can be used to determine whether the CSF level is normal. However, in patients with abnormal or unclear glucose metabolism, the CSF/average blood glucose ratio should be used to determine whether the CSF glucose level is normal.
我们旨在通过研究糖代谢正常和异常患者的血液与脑脊液葡萄糖水平之间的相关性，确定一种识别正常脑脊液（CSF）葡萄糖水平的方法。
195例患者根据其糖代谢情况分为两组。在腰椎穿刺前6、5、4、3、2、1和0小时采集脑脊液和指尖血的葡萄糖水平。使用SPSS 22.0软件进行统计分析。
在糖代谢正常和异常组中，腰椎穿刺前6、5、4、3、2、1和0小时脑脊液葡萄糖水平均随血糖水平升高而升高。在糖代谢正常组中，腰椎穿刺前0至6小时脑脊液/血糖比值范围为0.35 - 0.95，脑脊液/平均血糖比值范围为0.43 - 0.74。在糖代谢异常组中，腰椎穿刺前0至6小时脑脊液/血糖比值范围为0.25 - 1.2，脑脊液/平均血糖比值范围为0.33 - 0.78。
腰椎穿刺前6小时脑脊液葡萄糖水平受血糖水平影响。对于糖代谢正常的患者，直接测量脑脊液葡萄糖水平可用于确定脑脊液水平是否正常。然而，对于糖代谢异常或不明确的患者，应使用脑脊液/平均血糖比值来确定脑脊液葡萄糖水平是否正常。
