Ferkh Karim El, Nwaru Bright I, Griffiths Chris, Patel Anita, Sheikh Aziz
Asthma UK Centre for Applied Research, Centre for Medical Informatics, Usher Institute for Population Health Sciences, The University of Edinburgh, Edinburgh, UK.
School of Health Sciences, University of Tampere, Tampere, Finland.
BMJ Open. 2017 May 30;7(5):e015102. doi: 10.1136/bmjopen-2016-015102.
Asthma is associated with many comorbid conditions that have the potential to impact on its management, control and outcomes. These comorbid conditions have the potential to impact on healthcare expenditure. We plan to undertake a systematic review to synthesise the evidence on the healthcare costs associated with asthma comorbidity.
We will systematically search the following electronic databases between January 2000 and January 2017: National Health Service (NHS) Economic Evaluation Database, Google Scholar, Allied and Complementary Medicine Database (AMED), Global Health, PsychINFO, Medline, Embase, Institute for Scientific Information Web of Science and Cumulative Index to Nursing and Allied Health Literature. We will search the references in the identified studies for additional potential papers. Additional literature will be identified by contacting experts in the field and through searching of registers of ongoing studies. The review will include cost-effectiveness and economic modelling/evaluation studies and analytical observational epidemiology studies that have investigated the healthcare costs of asthma comorbidity. Two reviewers will independently screen studies and extract relevant data from included studies. Methodological quality of epidemiological studies will be assessed using the Effective Public Health Practice Project tool, while that of economic evaluation studies will be assessed using the Drummond checklist. This protocol has been published in International Prospective Register of Systematic Reviews (PROSPERO) database (No. CRD42016051005).
As there are no primary data collected, formal NHS ethical review is not necessary. The findings of this systematic review will be disseminated in a peer-reviewed journal and presented at relevant conferences.
CRD42016051005.
哮喘与许多共病状况相关，这些状况有可能影响其管理、控制及治疗结果。这些共病状况有可能影响医疗保健支出。我们计划进行一项系统评价，以综合有关哮喘合并症医疗成本的证据。
我们将在2000年1月至2017年1月期间系统检索以下电子数据库：国家卫生服务（NHS）经济评价数据库、谷歌学术、联合与补充医学数据库（AMED）、全球健康、心理信息数据库（PsychINFO）、医学索引数据库（Medline）、荷兰医学文摘数据库（Embase）、科学信息研究所科学网数据库（Institute for Scientific Information Web of Science）以及护理学与健康相关文献累积索引数据库（Cumulative Index to Nursing and Allied Health Literature）。我们将在已识别研究的参考文献中搜索其他潜在论文。通过联系该领域的专家并搜索正在进行的研究登记册来识别其他文献。该评价将纳入成本效益和经济建模/评价研究以及分析性观察性流行病学研究，这些研究调查了哮喘合并症的医疗成本。两名审查员将独立筛选研究，并从纳入研究中提取相关数据。流行病学研究的方法学质量将使用有效公共卫生实践项目工具进行评估，而经济评价研究的方法学质量将使用德拉蒙德清单进行评估。本方案已发表在国际前瞻性系统评价注册库（PROSPERO）数据库中（编号CRD42016051005）。
由于未收集原始数据，因此无需进行正式的NHS伦理审查。本系统评价的结果将在同行评审期刊上发表，并在相关会议上展示。
PROSPERO注册号：CRD42016051005。
