人类脊髓神经回路的发育与衰老
Development and aging of human spinal cord circuitries.
作者信息
Geertsen Svend Sparre, Willerslev-Olsen Maria, Lorentzen Jakob, Nielsen Jens Bo
机构信息
Neural Control of Movement Research Group, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen N, Denmark.
Department of Nutrition, Exercise, and Sports, University of Copenhagen, Copenhagen N, Denmark; and.
出版信息
J Neurophysiol. 2017 Aug 1;118(2):1133-1140. doi: 10.1152/jn.00103.2017. Epub 2017 May 31.
The neural motor circuitries in the spinal cord receive information from our senses and the rest of the nervous system and translate it into purposeful movements, which allow us to interact with the rest of the world. In this review, we discuss how these circuitries are established during early development and the extent to which they are shaped according to the demands of the body that they control and the environment with which the body has to interact. We also discuss how aging processes and physiological changes in our body are reflected in adaptations of activity in the spinal cord motor circuitries. The complex, multifaceted connectivity of the spinal cord motor circuitries allows them to generate vastly different movements and to adapt their activity to meet new challenges imposed by bodily changes or a changing environment. There are thus plenty of possibilities for adaptive changes in the spinal motor circuitries both early and late in life.
脊髓中的神经运动回路接收来自我们的感官及神经系统其他部分的信息，并将其转化为有目的的动作，使我们能够与外界互动。在本综述中，我们讨论这些回路在早期发育过程中是如何形成的，以及它们在多大程度上根据其所控制的身体需求和身体必须与之互动的环境而塑造。我们还讨论衰老过程和身体的生理变化如何反映在脊髓运动回路活动的适应性变化中。脊髓运动回路复杂、多方面的连接性使其能够产生极为不同的动作，并调整其活动以应对身体变化或不断变化的环境带来的新挑战。因此，无论是在生命早期还是晚期，脊髓运动回路都有大量进行适应性变化的可能性。
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