地中海饮食可降低澳大利亚老年男性和女性6个月后的F-异前列腺素和甘油三酯水平。
A Mediterranean Diet Reduces F-Isoprostanes and Triglycerides among Older Australian Men and Women after 6 Months.
作者信息
Davis Courtney Rose, Bryan Janet, Hodgson Jonathan M, Woodman Richard, Murphy Karen J
机构信息
Alliance for Research in Exercise, Nutrition, and Activity, School of Health Sciences, University of South Australia, Adelaide, South Australia, Australia;
School of Psychology, Social Work, and Social Policy, University of South Australia, Magill, Adelaide, South Australia, Australia.
出版信息
J Nutr. 2017 Jul;147(7):1348-1355. doi: 10.3945/jn.117.248419. Epub 2017 May 31.
Health benefits of a Mediterranean dietary pattern have been shown. However, there are few data on the effects of increased adherence to a Mediterranean diet (MedDiet) in non-Mediterranean countries. We aimed to determine whether adherence to a MedDiet would result in changes in plasma lipids, glucose and insulin, high-sensitivity C-reactive protein (hs-CRP), and F-isoprostanes (F-IsoPs) in an Australian population. The study was a 6-mo parallel, randomized, controlled dietary intervention trial. We recruited 166 participants aged ≥65 y. Participants were stratified on body mass index, sex, and age and assigned to receive either a MedDiet or a habitual diet (HabDiet). The primary outcome was cognitive function, reported elsewhere. As secondary outcomes, assessment of fasting total, LDL, and HDL cholesterol; triglycerides (TGs); glucose; insulin; hs-CRP; and F-IsoPs was completed at baseline and at 3 and 6 mo. The MedDiet group followed a prescribed diet containing 15-45 mL extra-virgin olive oil/d, abundant vegetables, fruit, nuts, legumes, and whole grains, as well as moderate fish, poultry, and dairy foods. Dietary intake was measured by 3-d weighed food records at baseline and at 2 and 4 mo. Results were analyzed by using linear mixed-effects models. Compared with the HabDiet, the MedDiet resulted in lower TGs at 3 mo (mean difference: -0.15 mmol/L; 95% CI: -0.23, -0.07 mmol/L; < 0.001) and 6 mo (mean difference: -0.09 mmol/L; 95% CI: -0.18, -0.01 mmol/L; = 0.03) and lower F-IsoPs at 3 mo (mean difference: -103.5 pmol/L; 95% CI: -154.2, -52.7 pmol/L; < 0.001) and 6 mo (-65.4 pmol/L; 95% CI: -117.1, -13.7 pmol/L; < 0.001). Lipoprotein, glucose and insulin, and hs-CRP concentrations were not significantly different between groups. A high adherence to a MedDiet for 6 mo resulted in a significant reduction in TGs and F-IsoPs among older Australians. This trial was registered at clinicaltrials.gov as ACTRN12613000602729.
地中海饮食模式对健康有益已得到证实。然而，在非地中海国家，关于增加对地中海饮食（MedDiet）的依从性所产生影响的数据较少。我们旨在确定在澳大利亚人群中，坚持地中海饮食是否会导致血浆脂质、葡萄糖和胰岛素、高敏C反应蛋白（hs-CRP）以及F-异前列腺素（F-IsoPs）发生变化。该研究是一项为期6个月的平行、随机、对照饮食干预试验。我们招募了166名年龄≥65岁的参与者。参与者根据体重指数、性别和年龄进行分层，并被分配接受地中海饮食或习惯饮食（HabDiet）。主要结局是认知功能，已在其他地方报道。作为次要结局，在基线以及3个月和6个月时完成对空腹总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇、甘油三酯（TGs）、葡萄糖、胰岛素、hs-CRP以及F-IsoPs的评估。地中海饮食组遵循规定饮食，每天包含15 - 45毫升特级初榨橄榄油、丰富的蔬菜、水果、坚果、豆类和全谷物，以及适量的鱼类、家禽和乳制品。通过在基线以及2个月和4个月时记录3天的称重食物摄入量来测量饮食摄入量。使用线性混合效应模型分析结果。与习惯饮食相比，地中海饮食在3个月时使甘油三酯降低（平均差异：-0.15 mmol/L；95%置信区间：-0.23，-0.07 mmol/L；P < 0.001），在6个月时也降低（平均差异：-0.09 mmol/L；95%置信区间：-0.18，-0.01 mmol/L；P = 0.03），并且在3个月时使F-异前列腺素降低（平均差异：-103.5 pmol/L；95%置信区间：-154.2，-52.7 pmol/L；P < 0.001），在6个月时降低（-65.4 pmol/L；95%置信区间：-117.1，-13.7 pmol/L；P < 0.001）。两组之间脂蛋白、葡萄糖和胰岛素以及hs-CRP浓度没有显著差异。在澳大利亚老年人中，坚持地中海饮食6个月可显著降低甘油三酯和F-异前列腺素。该试验已在clinicaltrials.gov上注册，注册号为ACTRN12613000602729。
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