Hanna A M R, Hartford A-M E, Morassaei S
Aging & Health Program, Department of Rehabilitation Science, Queen's University, Kingston, ON, Canada.
JAR Life. 2024 Dec 12;13:115-125. doi: 10.14283/jarlife.2024.18. eCollection 2024.
Diet is a key modifiable risk factor in many chronic diseases, including age-related diseases. The Mediterranean diet (MedDiet) is an extensively studied dietary pattern which has been proposed as a lifestyle intervention to promote healthy aging in the general population, due to its numerous health benefits. Randomized controlled trials (RCTs) have attempted to explore the mechanism(s) by which the MedDiet exerts its beneficial effects on aging. One proposed mechanism is that the MedDiet helps to slow down a process called 'inflamm-aging', a type of chronic, low-grade inflammation which contributes to aging. To explore the evidence supporting this hypothesized mechanism, we conducted a scoping review of existing RCTs which used a MedDiet intervention and assessed at least one molecular outcome of potential relevance to inflamm-aging. We identified 14 papers representing 12 unique RCTs. Based on our findings, we present 10 recommendations for the next clinical trial of the MedDiet in inflamm-aging.
饮食是包括与年龄相关疾病在内的许多慢性疾病中一个关键的可改变风险因素。地中海饮食（MedDiet）是一种经过广泛研究的饮食模式，因其众多健康益处，已被提议作为一种生活方式干预措施，以促进普通人群的健康衰老。随机对照试验（RCTs）试图探索地中海饮食对衰老产生有益影响的机制。一种提出的机制是，地中海饮食有助于减缓一种称为“炎症衰老”的过程，这是一种导致衰老的慢性低度炎症。为了探索支持这一假设机制的证据，我们对现有的使用地中海饮食干预并评估至少一个与炎症衰老潜在相关分子结果的随机对照试验进行了范围综述。我们确定了14篇论文，代表12项独特的随机对照试验。基于我们的研究结果，我们针对地中海饮食在炎症衰老方面的下一次临床试验提出了10条建议。
