Choe Sung Jay, Lee Solam, Choi Jaewoong, Lee Won-Soo
Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Ann Dermatol. 2017 Jun;29(3):276-282. doi: 10.5021/ad.2017.29.3.276. Epub 2017 May 11.
A variety of agents have been used to treat female pattern hair loss (FPHL), including topical minoxidil, topical 17α-estradiol, oral anti-androgen agents, and mineral supplements. Compared with these single agent regimens, combination therapies could be a better therapeutic option in expectation of superior treatment outcome.
This study was designed to determine the efficacy of a combination therapy consisting of topical 0.025% 17α-estradiol and 3% minoxidil in Korean patients with FPHL.
Therapeutic efficacy was evaluated in 34 women who applied topical 0.025% 17α-estradiol and 3% minoxidil once daily for more than 6 months. Phototrichogram analysis was performed before and after therapy. The efficacy was evaluated with respect to total hair count, hair caliber (as assessed by phototrichogram analysis), and photographic assessment.
Total hair count and hair caliber both increased from baseline to 6 months in patients treated with the combination therapy of topical 0.025% 17α-estradiol and 3% minoxidil (<0.001). Photographic assessment also revealed significant disease improvement, thus supporting the therapeutic efficacy.
A combination therapy consisting of topical 0.025% 17α-estradiol and 3% minoxidil can be tried as an effective treatment for FPHL.
多种药物已被用于治疗女性型脱发（FPHL），包括外用米诺地尔、外用17α-雌二醇、口服抗雄激素药物和矿物质补充剂。与这些单一药物治疗方案相比，联合治疗有望获得更好的治疗效果，可能是一种更好的治疗选择。
本研究旨在确定外用0.025% 17α-雌二醇和3%米诺地尔联合治疗韩国女性型脱发患者的疗效。
对34名女性进行治疗效果评估，她们每天外用一次0.025% 17α-雌二醇和3%米诺地尔，持续超过6个月。治疗前后进行毛发显微镜分析。从总毛发数量、毛发直径（通过毛发显微镜分析评估）和照片评估方面对疗效进行评估。
外用0.025% 17α-雌二醇和3%米诺地尔联合治疗的患者，从基线到6个月时总毛发数量和毛发直径均增加（<0.001）。照片评估也显示疾病有显著改善，从而支持了治疗效果。
外用0.025% 17α-雌二醇和3%米诺地尔联合治疗可作为女性型脱发的一种有效治疗方法尝试使用。
