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肢端雀斑样痣黑色素瘤，经切除诊断为惰性亚型：病例报告

Acral Lentiginous Melanoma, Indolent Subtype Diagnosed by Excision: A Case Report.

作者信息

Ohn Jungyoon, Bae Jeong Mo, Lim Ji Soo, Park Jong Seo, Yoon Hyun-Sun, Cho Soyun, Park Hyun-Sun

机构信息

Department of Dermatology, SMG-SNU Boramae Medical Center, Seoul, Korea.

Department of Pathology, SMG-SNU Boramae Medical Center, Seoul, Korea.

出版信息

Ann Dermatol. 2017 Jun;29(3):327-330. doi: 10.5021/ad.2017.29.3.327. Epub 2017 May 11.

DOI:10.5021/ad.2017.29.3.327
PMID:28566910
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5438940/
Abstract

Nail unit melanoma is a type of acral lentiginous melanoma and requires histopathologic examination for a confirmed diagnosis. However, inadequate biopsy techniques make definitive diagnosis difficult. A 61-year-old man presented with progressive nail pigmentation for 15 years, which was clinically highly suspicious for malignancy. Acral lentiginous melanoma was not detected in punch and longitudinal biopsy specimens, but excision tissue revealed melanoma. Acral lentiginous melanoma is known to have a heterogeneous pathologic manifestation depending on the pigmented region and the time it takes to progress. In this regard, excision can be considered as a first-line biopsy technique to diagnose acral lentiginous melanoma, indolent subtype.

摘要

甲单位黑色素瘤是肢端雀斑样痣黑色素瘤的一种类型，需要进行组织病理学检查以确诊。然而，活检技术不完善使得明确诊断困难。一名61岁男性，有15年的进行性甲色素沉着，临床上高度怀疑为恶性病变。在钻孔活检和纵向活检标本中未检测到肢端雀斑样痣黑色素瘤，但切除组织显示为黑色素瘤。已知肢端雀斑样痣黑色素瘤根据色素沉着区域和进展所需时间具有异质性病理表现。在这方面，切除可被视为诊断肢端雀斑样痣黑色素瘤惰性亚型的一线活检技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a61/5438940/3d90ba95788c/ad-29-327-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a61/5438940/3823ae05f14d/ad-29-327-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a61/5438940/7da1f40ef860/ad-29-327-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a61/5438940/3d90ba95788c/ad-29-327-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a61/5438940/3823ae05f14d/ad-29-327-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a61/5438940/7da1f40ef860/ad-29-327-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a61/5438940/3d90ba95788c/ad-29-327-g003.jpg

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本文引用的文献

1
Variable Sized Cellular Remnants in the Nail Plate of Longitudinal Melanonychia: Evidence of Subungual Melanoma.纵向黑甲甲板中大小可变的细胞残余物：甲下黑色素瘤的证据。
Ann Dermatol. 2015 Jun;27(3):328-9. doi: 10.5021/ad.2015.27.3.328. Epub 2015 May 29.
2
A case of subungual melanoma with tumor invasion sparing the nail matrix dermis.一例甲下黑色素瘤，肿瘤侵犯未累及甲母质真皮。
Ann Dermatol. 2014 Oct;26(5):655-7. doi: 10.5021/ad.2014.26.5.655. Epub 2014 Sep 26.
3
Site distribution of cutaneous melanoma in South Korea: a retrospective study at a single tertiary institution.
韩国皮肤黑色素瘤的部位分布：一项在单一三级医疗机构进行的回顾性研究。
Int J Dermatol. 2015 Jan;54(1):e38-9. doi: 10.1111/ijd.12572. Epub 2014 Oct 14.
4
Histopathological analysis of the progression pattern of subungual melanoma: late tendency of dermal invasion in the nail matrix area.甲下黑色素瘤进展模式的组织病理学分析：甲母质区真皮侵袭的晚期趋势。
Mod Pathol. 2014 Nov;27(11):1461-7. doi: 10.1038/modpathol.2014.65. Epub 2014 Apr 18.
5
Acral lentiginous melanoma: indolent subtype with long radial growth phase.肢端雀斑样痣黑色素瘤：具有较长径向生长期的惰性亚型。
Am J Dermatopathol. 2014 Feb;36(2):142-7. doi: 10.1097/DAD.0b013e31829bea8b.
6
Acral lentiginous melanoma in situ: a diagnostic and management challenge.原位肢端雀斑样黑素瘤：诊断与治疗难点。
Cancers (Basel). 2010 Apr 20;2(2):642-52. doi: 10.3390/cancers2020642.
7
Conservative surgical management of subungual (matrix derived) melanoma: report of seven cases and literature review.甲下（基质来源）黑色素瘤的保守性手术治疗：7 例报告及文献复习。
Br J Dermatol. 2011 Oct;165(4):852-8. doi: 10.1111/j.1365-2133.2011.10477.x. Epub 2011 Aug 4.
8
Dermoscopic features of acral lentiginous melanoma in a large series of 110 cases in a white population.肢端黑色素瘤 110 例白人患者的皮肤镜特征。
Br J Dermatol. 2010 Apr;162(4):765-71. doi: 10.1111/j.1365-2133.2009.09594.x. Epub 2009 Nov 18.
9
Subungual melanoma: histological examination of 50 cases from early stage to bone invasion.甲下黑色素瘤：50例从早期至骨浸润病例的组织学检查
J Dermatol. 2008 Nov;35(11):695-703. doi: 10.1111/j.1346-8138.2008.00551.x.
10
Subungual melanoma: a study of 124 cases highlighting features of early lesions, potential pitfalls in diagnosis, and guidelines for histologic reporting.甲下黑色素瘤：一项对124例病例的研究，突出早期病变特征、诊断中的潜在陷阱以及组织学报告指南。
Am J Surg Pathol. 2007 Dec;31(12):1902-12. doi: 10.1097/PAS.0b013e318073c600.