Demirci Kadir, Yildirim Baş Funda, Arslan Bahriye, Salman Zeliha, Akpinar Abdullah, Demirdaş Arif
Department of Psychiatry, Süleyman Demirel University School of Medicine, Isparta, Turkey.
Department of Family Medicine, Süleyman Demirel University School of Medicine, Isparta, Turkey.
Noro Psikiyatr Ars. 2017 Mar;54(1):72-77. doi: 10.5152/npa.2016.12464. Epub 2016 Mar 4.
The aim of this study was to investigate symptoms and diagnoses of Adult-Attention Deficit/Hyperactivity Disorder (ADHD) in women with iron deficiency anemia, to evaluate relationship between ADHD with clinical features and to compare with the women without iron deficiency anemia.
Eighty-three newly diagnosed iron deficiency anemia patients and 70 healthy controls were included in this study. All participants were assessed using a sociodemographic form, Structured Clinical Interview I (SCID-I), Wender Utah Rating Scale (WURS); Moreover, participants having WURS scores 36 and above were also assessed using the Adult ADD/ADHD Evaluation Scale and interviewed according to DSM-5 criteria.
In the study, 22.9% of patients with iron deficiency anemia and 12.9% of healthy controls were found to have WURS scores 36 and above. Fifteen patients (18.1%) in iron deficiency anemia group and two patients (2.9%) in control group had adult ADHD, when they were evaluated with Adult ADD/ADHD Evaluation Scale and interviewed according to DSM-5 criteria (p=0.007). The patients with iron deficiency anemia had significantly higher WURS scores compared to controls (p=0.002). The levels of iron and ferritin had negative correlation (r=-0.166, p<0.05; r=-0.255, p<0.01, respectively) and the levels of serum iron binding capacity had positive correlation (r=0.255, p<0.01) with the scores of WURS.
The prevalence of adult ADHD is higher than those reported for general population in patients with iron deficiency anemia. Early diagnose and treatment of adult ADHD may positively contribute to the patients with iron deficiency anemia.
本研究旨在调查缺铁性贫血女性成人注意力缺陷多动障碍（ADHD）的症状和诊断情况，评估ADHD与临床特征之间的关系，并与无缺铁性贫血的女性进行比较。
本研究纳入了83例新诊断的缺铁性贫血患者和70例健康对照。所有参与者均使用社会人口学表格、结构化临床访谈I（SCID-I）、温德犹他评定量表（WURS）进行评估；此外，WURS得分36及以上的参与者还使用成人注意力缺陷多动障碍评估量表进行评估，并根据DSM-5标准进行访谈。
在本研究中，发现22.9%的缺铁性贫血患者和12.9%的健康对照WURS得分36及以上。当使用成人注意力缺陷多动障碍评估量表并根据DSM-5标准进行访谈时，缺铁性贫血组有15例患者（18.1%）患有成人ADHD，对照组有2例患者（2.9%）患有成人ADHD（p=0.007）。与对照组相比，缺铁性贫血患者的WURS得分显著更高（p=0.002）。铁和铁蛋白水平与WURS得分呈负相关（分别为r=-0.166，p<0.05；r=-0.255，p<0.01），血清铁结合能力水平与WURS得分呈正相关（r=0.255，p<0.01）。
缺铁性贫血患者中成人ADHD的患病率高于一般人群报告的患病率。成人ADHD的早期诊断和治疗可能对缺铁性贫血患者有积极作用。
