Lahat Eli, Heyman Eli, Livne Amir, Goldman Michael, Berkovitch Matitiahu, Zachor Ditza
Pediatric Neurology Unit, Asaf Harofeh Medical Center, Zerifin, Israel.
Isr Med Assoc J. 2011 Sep;13(9):530-3.
Several studies have suggested that iron deficiency may be related to the pathophysiology of attention deficit hyperactivity disorder (ADHD) due to the role of iron in the production of dopamine and noradrenaline.
To evaluate the status of iron deficiency in ADHD children, using ferritin levels, a reliable measure of iron storage in body tissue, as an iron status marker, and to investigate a possible correlation between ferritin levels and the diagnosis of ADHD.
The study group included 113 newly referred ADHD children aged 5-15 years (mean age 8.8 +/- 2.7).
Ferritin levels were below 20 ng/ml in 67 children (59%) and above 20 ng/ml in 46 (41%). There was a very low inverse statistical correlation between scores on Conners' Rating Scale and ferritin levels, probably without clinical significance.
Our findings suggest that low iron stores may be related to ADHD pathophysiology; therefore, ferritin should be included in the overall evaluation of children with ADHD.
多项研究表明，由于铁在多巴胺和去甲肾上腺素生成过程中的作用，缺铁可能与注意力缺陷多动障碍（ADHD）的病理生理学有关。
以铁蛋白水平作为体内组织铁储存的可靠指标，评估ADHD儿童的缺铁状况，并研究铁蛋白水平与ADHD诊断之间的可能相关性。
研究组包括113名新转诊的5至15岁ADHD儿童（平均年龄8.8 +/- 2.7岁）。
67名儿童（59%）的铁蛋白水平低于20 ng/ml，46名儿童（41%）的铁蛋白水平高于20 ng/ml。康纳斯评定量表得分与铁蛋白水平之间存在极低的负相关，可能无临床意义。
我们的研究结果表明，低铁储存可能与ADHD的病理生理学有关；因此，铁蛋白应纳入ADHD儿童的全面评估中。
