Tohidi Sepehr, Bidabadi Elham, Khosousi Mohammad-Javad, Amoukhteh Melika, Kousha Maryam, Mashouf Parham, Shahraki Tamkin
Student Research Committee, School of Medicine, Guilan Universtiy of Medical Sciences, Rasht, Iran.
Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Clin Psychopharmacol Neurosci. 2021 Nov 30;19(4):712-720. doi: 10.9758/cpn.2021.19.4.712.
To evaluate the effect of iron on the attention deficit hyperactivity disorder, treated with methylphenidate.
This double-blind, randomized placebo-controlled clinical trial was performed on 50 children with attention deficit hyperactivity disorder under the treatment of methylphenidate, with ferritin levels below 30 ng/ml and absence of anemia. They were randomly assigned into two groups of ferrous sulfate and placebo, for 12 weeks. Conners' Parent Rating Scale (CPRS) was used to assess the outcome in the first, sixth, and twelfth weeks.
Almost all CPRS subscales improved in the ferrous sulfate group from the baseline to the endpoint, although only the changes in conduct subscale scores were significant ( = 0.003). There was no significant difference in score changes between two groups in intergroup comparison. Also, the score of learning problems ( = 0.007) in the first six weeks, and conduct ( = 0.023) and psychosomatic ( = 0.018) subscales in the second six weeks were improved in the ferrous sulfate group compared with the placebo group.
Our study showed promising effects of iron supplementation in the improvement of subscales of the CPRS.
评估铁剂对接受哌甲酯治疗的注意力缺陷多动障碍的影响。
本双盲、随机、安慰剂对照临床试验纳入50例接受哌甲酯治疗、铁蛋白水平低于30 ng/ml且无贫血的注意力缺陷多动障碍儿童。他们被随机分为硫酸亚铁组和安慰剂组，治疗12周。在第1、6和12周使用康纳斯父母评定量表（CPRS）评估结果。
从基线到终点，硫酸亚铁组几乎所有CPRS分量表均有改善，尽管只有品行分量表得分的变化具有显著性（P = 0.003）。组间比较两组得分变化无显著差异。此外，与安慰剂组相比，硫酸亚铁组在前六周学习问题得分（P = 0.007）以及后六周品行（P = 0.023）和身心（P = 0.018）分量表得分有所改善。
我们的研究表明补充铁剂在改善CPRS分量表方面有显著效果。
