Giesen-Crouse E, Fandeleur P, Schmidt M, Schwartz J, Imbs J L
Institut de Pharmacologie (UA 589 CNRS, U206 Inserm), Faculté de Médecine, Strasbourg, France.
J Hypertens Suppl. 1985 Dec;3(3):S211-3.
Receptors which bind [3H]-piretanide were demonstrated on membranes prepared from renal medulla and cortex. They exhibit all the characteristics of a specific receptor such as high affinity, specificity, tissue selectivity, reversible binding kinetics and proportionality between affinity and diuretic effect. Medullary and cortical receptors are clearly distinct since they have different ion requirements.
在从肾髓质和皮质制备的膜上证实了能结合[3H] - 吡咯他尼的受体。它们展现出特异性受体的所有特征，如高亲和力、特异性、组织选择性、可逆结合动力学以及亲和力与利尿作用之间的比例关系。髓质和皮质受体明显不同，因为它们有不同的离子需求。
